METABOLIC & HORMONAL IMPACT OF BINGE EATING IN NORMAL WOMEN--PILOT STUDY

新陈代谢

• 批准号: 6280004
• 负责人: ANN E TAYLOR
• 金额: $ 2.74万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280004
• 关键词: binge eating disorder; blood chemistry; blood glucose; caloric dietary content; catecholamines; clinical research; clinical trials; cortisol; diet therapy; dietary control; female; glucose tolerance test; hormone regulation /control mechanism; human subject; human therapy evaluation; insulin; insulin sensitivity /resistance; menstrual cycle; nutrition related tag; urinalysis

This is a pilot study to determine the optimal length of dietary intervention for subsequent studies. Normal women will be studied during the early follicular phase of two consecutive menstrual cycles. The women will be admitted to the GCRC for 3 days of a controlled diet, which will consist of either 3 meals plus a snack daily, or the same number of daily weight-maintenance calories given as a single evening meal. On the third day of each diet, each subject will undergo 24 hours of q15 minute frequent blood sampling for glucose and insulin. Each women will undergo a 20 minute insulin tolerance test on the following morning before discharge. The subjects will be readmitted in the following early follicular phase for the same protocol on the oppsite diet. Daily 24 hour urine collections will be made each day of each admission to evaluate stress by urinary cortisol and catecholamine levels. Six to eight normal women will be studied in this pilot to determine if three days of a controlled diet are sufficient to induce a change in insulin levels. Subsequently, the appropriate study length will be utilized in future studies of hyperandrogenic and diabetic women along with additional analyses.

这是一项试点研究，以确定饮食的最佳长度 干预后续研究。普通女性将被研究 在两个连续的月经周期的早期卵泡期。 这些妇女将被送入GCRC，以控制饮食3天， 这将包括3顿饭和每天的小吃或相同的 每天的重量维护卡路里的卡路里数量为一个晚上 一顿饭。在每个饮食的第三天，每个受试者都会接受24小时 Q15分钟的葡萄糖和胰岛素频繁抽样。每个 女性将在以下 出院前的早晨。主题将在 遵循相同协议的早期卵泡阶段在Oppsite上 饮食。每天每天每天每天进行24小时尿液 接受尿皮质醇和儿茶酚胺评估压力的门票 水平。这名飞行员将研究六到八名普通妇女 确定受控饮食的三天是否足以诱导 胰岛素水平的变化。随后，适当的研究长度 将来将在未来的超雄激素和糖尿病妇女的研究中使用 以及其他分析。