ACTIVATED C PROTEIN RESISTANCE AS AN OPERATIVE RISK FOR VENOUS THROMBOSIS

活化 C 蛋白抵抗是静脉血栓形成的手术风险

• 批准号: 6279325
• 负责人: ALAN SAVEN
• 金额: $ 2.73万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279325
• 关键词: blood banks; clinical research; disease /disorder proneness /risk; genetic registry /resource /referral center; genetic susceptibility; human subject; postoperative complications; protein C; venous thrombosis

This study aimed to study the prevalence of activated protein C resistance in a case controlled group of patients who underwent high thrombotic risk operations and developed thrombosis. Secondary goals are to study the interplay of other genetic risk factors for thrombosis and activated protein C resistance. It also aimed to develop a bank of stored serum and DNA coupled with a database of patient information that can be used to study yet undiscovered risks for thrombosis.

这项研究旨在研究活化蛋白C的患病率 在接受高的患者的病例受控组中的抗药性 血小板风险操作并发展为血栓形成。次要目标是 研究其他遗传危险因素的相互作用 活化的蛋白C耐药性。它还旨在发展 存储的血清和DNA与患者信息的数据库结合在一起 可用于研究血栓形成尚未发现的风险。