THERMAL CHARACTERIZATION OF HUMAN BREAST TUMORS

人类乳腺肿瘤的热表征

• 批准号: 2895821
• 负责人: KENNETH L CARR
• 金额: $ 36.82万
• 依托单位: MICROWAVE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-25 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2895821
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; body temperature; breast neoplasm /cancer diagnosis; breast neoplasms; clinical biomedical equipment; clinical research; computer assisted diagnosis; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; female; fine needle aspiration; histopathology; human subject; immunocytochemistry; mammography; microwave radiation; neoplasm /cancer blood supply; noninvasive diagnosis; radiography; thermography; thermometry; women's health

The long-term objective of this research is to improve breast cancer management by utilizing thermal information as an adjunct to mammography to aid in clinical decisions when confronted with equivocal mammograms. Before this objective is reached, the relationship of thermal abnormalities to breast cancer must be firmly established. This Phase II proposal is designed to obtain noninvasive thermal information using passive microwave radiometry in both breasts of approximately 1000 women scheduled to have needle localization procedures and breast biopsy. This noninvasive approach is a medically acceptable way to gain the necessary information from both breasts in each patient to permit left- to-right thermal comparisons between the cancer-affected and normal breasts. The strength of this Phase II proposal is that mammograms and biopsy-proven pathology will be available on each case. This will permit correlative studies between breast cancer thermogenicity with other factors, such as tumor histopathology, tumor size, grade and so on, in addition to angiogenesis determined on archival specimens. It may be possible to increase the yield of positive biopsies and reduce negative biopsies if women with equivocal mammograms and thermally abnormal lesions were biopsied, while women with equivocal mammograms and thermally normal lesions were deferred for biopsy pending further evidence indicating biopsy. PROPOSED COMMERCIAL APPLICATION: The long-term objective of this research is to improve breast cancer management by utilizing thermal information as an adjunct to mammography to aid in clinical decisions when confronted with equivocal mammograms. The data obtained from this study could lead to the development of improved detection techniques and equipment, based on noninvasive thermal sensing, as an adjunct to mammography.

这项研究的长期目标是改善乳腺癌 利用热信息作为乳房 X 光检查的辅助手段进行管理 在遇到模棱两可的乳房X光检查时帮助做出临床决策。 在达到这个目标之前，热关系 必须明确乳腺癌的异常情况。 这一阶段 II提案旨在利用以下方式获取非侵入性热信息： 对约 1000 名女性的双侧乳房进行被动微波辐射测量 计划进行针定位程序和乳房活检。 这种非侵入性方法是医学上可接受的获得 来自每位患者双侧乳房的必要信息，以允许左 受癌症影响的人和正常人之间的向右热比较 乳房。 第二阶段提案的优势在于乳房 X 光检查和 每个病例都可以获得活检证实的病理学结果。 这将 允许乳腺癌热原性与 其他因素，如肿瘤组织病理学、肿瘤大小、分级等 除了根据档案标本确定的血管生成之外。 它 可能会增加阳性活检的产量并减少 如果女性的乳房X光检查和热检查结果模棱两可，则活检呈阴性 对异常病变进行活检，而乳房 X 光检查结果模棱两可的女性 热正常病变被推迟进行活检，等待进一步检查 表明活检的证据。 拟议的商业应用： 这项研究的长期目标是改善乳腺癌 利用热信息作为乳房 X 光检查的辅助手段进行管理 在遇到模棱两可的乳房X光检查时帮助做出临床决策。 从这项研究中获得的数据可能会导致开发 改进的检测技术和设备，基于无创 热传感，作为乳房X光检查的辅助手段。