ANALYSIS DEVELOPMENT COMPONENT

分析开发组件

• 批准号: 6109128
• 负责人: MICHAEL Q ZHANG
• 金额: $ 20万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-18 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6109128
• 关键词: chromosomes; computer assisted sequence analysis; computer program /software; computer system design /evaluation; genetic mapping; human genetic material tag; mathematical model; model design /development; nucleic acid sequence; statistics /biometry

A grant effort is underway to sequence the entire human genome. Identification of functional sequence elements by computational tools has become increasingly important. Our long time goal is to use mathematical and statistical methods to identify most important functional elements-- protein coding genes and their regulatory elements from a large genomic sequences. Recently, we have developed a new human exon-finder called MZEF (PNAS 94:565-568, 1997), based on a modern multivariate statistical pattern recognition technique. In the proposed human chromosome 18 sequencing project, we plan to improve and to extend our MZEF in a real large-scale sequence production setting and to integrate new methods (especially first and last exon prediction methods) to be developed under the other funded research projects in Dr. Zhang's Laboratory. We shall interact with the informatics-core and other components closedly in order to test for accuracy, efficiency and scalability. Developing computational methods to assist rapid annotation of the gnome will also be vital for achieving the goals of Human Genome Project, which in turn will have a profound impact on human health and medicine.

一项资助工作正在进行中，以对整个人类基因组进行测序。 通过计算工具识别功能序列元素已 变得越来越重要。我们的长期目标是使用数学 和统计方法来识别最重要的功能元素—— 来自大型基因组的蛋白质编码基因及其调控元件 序列。最近，我们开发了一种新的人类外显子探测器，称为 MZEF (PNAS 94:565-568, 1997)，基于现代多元统计 模式识别技术。在提议的人类18号染色体中 测序项目，我们计划在实际中改进和扩展我们的 MZEF 大规模序列生产设置并整合新方法 （特别是第一个和最后一个外显子预测方法）将在 另一个资助张博士实验室的研究项目。我们将 与信息学核心和其他组件按顺序紧密交互 测试准确性、效率和可扩展性。发展计算能力 协助快速注释侏儒的方法对于 实现人类基因组计划的目标，这反过来又将有一个 对人类健康和医学产生深远影响。