PULSATILE GONADOTROPIN RELEASE AND USE OF GNRH IN WOMEN WITH CENTRAL AMENORRHEA

中央性闭经女性的脉动促性腺激素释放和 GNRH 的使用

• 批准号: 5221426
• 负责人: WILLIAM S EVANS
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5221426
• 关键词: amenorrhea; clinical research; endocrine disorder chemotherapy; endocrine pharmacology; female; follicle stimulating hormone; gonadotropin releasing factor; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; luteinizing hormone; reproductive system disorder chemotherapy; secretion

This study will address two major issues: 1) characterization of the pulsatile secretion of immunoactive LH and FSH and bioactive LH in women with central amenorrhea by using state-of-the-art pulse analysis techniques and 2) definition of the effect of exogenous pulsatile GnRH on immunoactive LH and FSH and bioactive LH in women with central amenorrhea.

本研究将解决两个主要问题：1） 女性免疫活性 LH 和 FSH 以及生物活性 LH 的脉冲式分泌 通过使用最先进的脉冲分析来治疗中枢性闭经 技术和 2) 外源性脉动 GnRH 效应的定义 中枢神经系统疾病女性的免疫活性 LH 和 FSH 以及生物活性 LH 闭经。