ACETYL CARNITINE AS A TREATMENT FOR ALZHEIMERS DISEASE

乙酰肉碱治疗阿尔茨海默病

• 批准号: 6117604
• 负责人: RICHARD P MAYEUX
• 金额: $ 2.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117604
• 关键词: Alzheimer's disease; brain disorder chemotherapy; brain metabolism; carnitine; clinical research; clinical trials; drug screening /evaluation; human subject; human therapy evaluation

Acetyl-Carnitine is a compound which has two primary actions: it is possibly a cholinergic agonist and it may enhance cerebral metabolism by activating mitochondrial activity. Its efficacy in Alzheimer's disease is suggested by animal studies and this is the first US clinical trial of this agent. A parallel double blind study of 25 subjects will take place as a preliminary study to determine whether a nation-wide trial should take place.

乙酰肉碱是一种具有两个主要动作的化合物：它是 可能是胆碱能激动剂，它可能增强大脑代谢 通过激活线粒体活性。 它在阿尔茨海默氏症中的功效 动物研究提出了疾病，这是美国第一个临床 该代理商的试验。 对25名受试者的平行双盲研究将 作为一项初步研究，以确定是否在全国范​​围内 审判应该进行。