COMMUNITY AND COHORT SURVEILLANCE PROGRAMS

社区和群体监测计划

• 批准号: 6352478
• 负责人: LLOYD E CHAMBLESS
• 金额: $ 84.56万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352478
• 关键词: alcoholic beverage consumption; atherosclerosis; behavioral /social science research tag; blood lipid; body physical activity; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; clinical research; coronary disorder; diabetes mellitus; diet; disease /disorder proneness /risk; eye fundus photography; family genetics; hemostasis; human mortality; human subject; hypertension; longitudinal human study; magnetic resonance imaging; myocardial infarction; nutrition related tag; racial /ethnic difference; smoking; statistical service /center

ARIC is a large-scale, long-term program that will measure associations of established and suspected coronary heart disease risk factors (CHD) with both atherosclerosis and new CHD events such as myocardial infarction in men and women from four diverse communities. The project has two components: community surveillance of morbidity and mortality, and repeated examinations of a representative cohort of men and women in each community. The community surveillance involves abstracting hospital records and death certificates and investigating out-of- hospital deaths. The representative cohorts include 4,000 persons from each community. Three of these reflect the ethnic composition of the communities in which they live; one cohort is black. All cohort participants are examined four times (1987-90), and 1990-93, 1993-96, and 1996-99), and contacted annually to update their medical histories. Atherosclerosis is measured by carotid and ultrasonography. Arteriosclerosis is measured using retinal photography. Cerebrovascular disease is assessed using MRI in a sample of black and white participants. Rick factors studied include: blood lipids, lipoprotein cholesterols, and apolipoproteins; plasma hemostatic factors; diabetes and glucose intolerance; blood chemistries and hematology and indicators and infectious and inflammatory disease; DNA markers of these risk factors; sitting, supine and standing blood pressures to track the development of hypertension; anthropometry; fasting blood glucose and insulin level as predictors of diabetes; ECG findings; heart rate variability; cigarette and alcohol use; physical activity level; dietary aspects; and family history. The diverse communities can be compared with respect to CHD incidence and medical care and, through the cohort component, with respect to risk factors and peripheral atherosclerosis. The results will provide a measure of the variation in the distribution and determinants of CHD in the U.S. and, within the limits of ecologic analysis, suggest possible reasons for observed differences. The contractor serves as the coordinating center for ARIC.

ARIC是一个大规模的长期计划，将衡量关联 已建立和怀疑的冠心病危险因素（CHD） 既有动脉粥样硬化和新冠心病事件，例如心肌 来自四个不同社区的男性和女人的梗塞。项目 有两个组成部分：社区监视发病率和死亡率， 并反复对一组代表性的男人和女人进行检查 在每个社区。社区监视涉及抽象 医院记录和死亡证明和调查 医院死亡。代表人群包括4,000人 每个社区。其中三个反映了 他们居住的社区；一个队列是黑色。 所有队列参与者进行了四次检查（1987-90）和1990 - 93年， 1993 - 96年和1996 - 99年），每年联系以更新其医疗 历史。动脉粥样硬化是通过颈动脉和超声检查测量的。 使用视网膜摄影测量动脉硬化。脑血管 在黑白样品中使用MRI评估疾病 参与者。研究的瑞克因子包括：血脂，脂蛋白 胆固醇和载脂蛋白；血浆止血因素；糖尿病 和葡萄糖不耐症；血液化学和血液学和指标 以及传染性和炎症性疾病；这些风险的DNA标记 因素；坐着，仰卧和站立的血压追踪 高血压的发展；人体测定法；禁食的血糖和 胰岛素水平为糖尿病的预测因子；心电图发现；心率 可变性；香烟和饮酒；体育锻炼水平；饮食 方面；和家族史。 可以将各种社区在CHD发病率方面进行比较 和医疗服务，以及通过队列组成部分的风险 因素和周围动脉粥样硬化。结果将提供 测量冠心病分布和决定因素的变化 美国，在生态分析的范围内，可能 观察到差异的原因。 承包商是ARIC协调中心。