IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS

铁过量和遗传性血色素沉着症

• 批准号: 6222856
• 负责人: JOHN H ECKFELDT
• 金额: $ 16.19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-31 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6222856
• 关键词: clinical research; epidemiology; family genetics; gene environment interaction; genetic polymorphism; genetic screening; genetic susceptibility; hereditary hemochromatosis; human subject; iron disorder; linkage mapping; primary care physician

The Iron Overload and Hereditary Hemochromatosis Study is an epidemiologic study of the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in a multi-center, multi-ethnic, primary care-based sample of 100,000 adults. The information will be used to determine the feasibility and potential individual and public health benefits and risks of primary care-based screening and intervention for iron overload and hereditary hemochromatosis. The 100,000 participants will be recruited from five field centers for screening. Following the screening, a clinical examination will be conducted in selected individuals. The final component of the study is a family study which will use genome scanning and assessment of linkage to identify genetic variants related to the expression of iron overload and hereditary hemochromatosis disorders.

铁超负荷和遗传性血色素沉着研究研究是一项关于铁超负荷和遗传性血色素体在多中心，多中心的，基于100,000名成年人的基于多中心的临床，个人和社会影响的流行病学研究以及潜在的临床，个人和社会影响。该信息将用于确定基于初级保健的筛查以及对铁超载和遗传性血色素沉着症的可行性和潜在的个人和公共卫生益处以及风险。 100,000名参与者将从五个现场中心招募进行筛查。筛选后，将在选定的个体中进行临床检查。该研究的最终组成部分是一项家庭研究，该研究将使用基因组扫描和评估联系来确定与铁超载和遗传性血色素沉着症的表达相关的遗传变异。