CENTRAL NERVOUS SYSTEM MEDIATION OF AFFECTIVE AUTONOMIC/BEHAVIORAL RESPONSES

中枢神经系统调节情感自主/行为反应

• 批准号: 5213606
• 负责人: PHILIP M MCCABE
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5213606
• 关键词: atherosclerosis; attention; baroreceptors; behavioral medicine; brain electrical activity; brain stem; cardiovascular disorder; cardiovascular function; chemoreceptors; echocardiography; electrostimulus; environmental stressor; ethology; experimental brain lesion; hormone regulation /control mechanism; hypothalamus; laboratory rabbit; lidocaine; neural information processing; neuroanatomy; physiologic stressor; psychophysiology; single cell analysis; sympathetic nervous system; vasomotion

The overall objective of these experiments is to advance our understanding of the neurophysiological mechanisms that underlie responses of the sympathetic nervous system to emotional stressors in an animal model. Project 4 focuses upon two integrated autonomic/behavioral responses to emotional stressors in which the sympathetic nervous system predominates; the defense reaction and the vigilance reaction: This project seeks to delineate the functional efferent pathways that mediate the cardiovascular components of the defense and vigilance reactions and to determine how critical CNS sites interact to produce these integrated patterns of response to stressors. Although attenuation of cardiovascular reactivity is a goal of many clinical interventions, the CNS mechanisms involved in the modulation of the gain of affective response systems are poorly understood. Accordingly, one of the objectives of the current proposal is to assess the mechanisms by which sensory information from chemoreceptor and baroreceptors modulate cardiovascular reactivity associated with the defense reaction and the vigilance reaction. By using electrophysiological, neuroanatomical, and behavioral techniques the following specific aims will be addressed; 1) to continue the line of inquiry initiated during the previous funding period which will use a retrograde analysis to trace the efferent pathways that mediate athe defense reaction and the vigilance reaction. 2) to use the lidocaine reversible lesioning technique and single cell recording techniques to determine the function of integrative sites located ina the amygdala, hypothalamus and periaqueductal grey (PAG) ina the organization and regulation the defense reaction; 3) to use lidocaine lesions and single cells recording techniques to asses mechanisms of feedback regulation of cardiovascular reactivity by information from baroreceptor and chemoreceptive afferents; 4) to use a retrograde analysis to map pathways from baroreceptors to CNS sites that mediate feedback regulation of the defense reaction.

这些实验的总体目标是增进我们的理解 神经生理学机制是反应的基础 动物模型中交感神经系统对情绪压力源的影响。 项目 4 侧重于两种综合自主/行为反应 交感神经系统占主导地位的情绪压力； 防御反应和警惕反应：该项目旨在 描绘介导心血管的功能性传出通路 防御和警戒反应的组成部分，并确定如何 关键的中枢神经系统站点相互作用产生这些集成模式 对压力源的反应。 虽然心血管反应性减弱 是许多临床干预的目标，中枢神经系统机制涉及 情感反应系统增益的调节很差 明白了。 因此，当前提案的目标之一是 评估来自化学感受器的感觉信息的机制 和压力感受器调节与相关的心血管反应性 防御反应和警惕反应。 通过使用 电生理学、神经解剖学和行为技术 将解决以下具体目标； 1）继续行 在上一个资助期间发起的调查将使用 逆行分析追踪介导 athe 的传出通路 防御反应和警惕反应。 2）使用利多卡因 可逆损伤技术和单细胞记录技术 确定位于杏仁核的整合位点的功能， 下丘脑和导水管周围灰质（PAG）在组织中和 调节防御反应； 3）使用利多卡因治疗病灶并单用 细胞记录技术评估反馈调节机制 来自压力感受器的信息的心血管反应性和 化学感受传入； 4）使用逆行分析来绘制路径 从压力感受器到中枢神经系统站点，介导反馈调节 防御反应。