Lessons for the future: Qualifying and quantifying South Asia's first widespread ciguatera poisoning outbreak

未来的教训：对南亚首次大范围雪卡中毒爆发进行定性和量化

• 批准号: NE/P018947/1
• 负责人: Lucy Millicent Turner
• 金额: $ 6.65万
• 依托单位: Plymouth University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FP018947%2F1
• 关键词: Lessons; future; Qualifying; quantifying; South

South Asia has long had a fish eating tradition as well as a growing domestic and export fishing industry. However, recently there have been sporadic reports of ciguatera fish poisoning (CFP) from this region. This is a circumtropical disease transmitted by eating carnivorous fishes that contain toxins accumulated from their food and is characterised by gastrointestinal and neurological symptoms which may result in disablement and/or death. Despite the known presence of the dinoflagellate Gambierdiscus spp., one of the most common causative agents of CFP, in the region (Indian Ocean and Arabian Sea) there has been no previously recorded large-scale CFP incident in this area until now. On 1st October 2016 South Asia's first widespread CFP outbreak occurred in the city of Mangalore, Karnataka, on the coast of SW India, resulting in several hundred hospital attendances and admissions. This is believed to be as a result of the consumption of locally caught carnivorous fish, such as the red snapper, Lutjanus bohar, contaminated with ciguatera toxins. These fish were originally intended for a fish processing plant in the city but were also sold at the Mangalore fish market. This recent outbreak presents a unique opportunity to qualify and quantify the presence of the causative algal species, whilst at the same time conduct state-of-the-art toxin analysis of contaminated seafood samples in a region of the world currently underrepresented both in terms of sampling coverage and technological analysis of an algal-born toxin outbreak event. Increased seawater temperatures and lowered salinity are known to favour the regional dinoflagellate community in general, and specifically Gambierdiscus spp. The previous 12 months have seen sea surface temperatures in the Indian Ocean consistently 0.5-1.0 degrees C above average coinciding with the ongoing El Niño Southern Oscillation and this season's monsoon has been particularly sustained, lowering coastal salinity. Data gathered during the proposed study will allow us to make predictions for the occurrence of further outbreaks of CFP along the South Asian coastline and elsewhere, including in the face of global climate change. Our aim to implement a rapid response screening and management programme in response to future CFP events will help to ensure the health and wellbeing of those who depend on fishing as a protein and/or economic resource.

南亚长期以来一直具有鱼类的饮食传统以及不断发展的国内和出口捕鱼业。但是，最近有零星的报道来自该地区的Ciguatera鱼中毒（CFP）。这是一种通过食用食物中含有毒素从其食物中积累的毒素的食肉鱼传播的巨大疾病，其特征是胃肠道和神经系统症状，可能导致残疾和/或死亡。尽管已知存在CFP最常见的病原体之一的Winoflagellate Gambierdiscus spp。，该地区（印度洋和阿拉伯海）的存在，但直到现在，该地区尚未在该地区记录过大规模的CFP事件。 2016年10月1日，南亚的首次宽度CFP爆发发生在印度西南部海岸的卡纳塔克邦芒格洛尔市，导致了数百家医院出勤和入学率。据信这是由于食用当地捕获的食肉鱼的结果，例如红鲷鱼lutjanus bohar，被雪茄毒素污染。这些鱼最初是用于该市的鱼类加工厂的，但也在芒格洛尔鱼市场上出售。这次最近的暴发提供了一个独特的机会，可以限定和量化因果藻类物种的存在，而同时进行了最先进的毒素毒素分析，对目前在世界各地的污染海鲜样品进行了对污染的海鲜样品的分析，目前在对藻类毒素爆发事件的采样覆盖范围和技术分析方面的表现不足。众所周知，海水温度升高和降低的盐度会有利于整个区域的鞭毛藻社区，特别是甘比尔迪斯库斯菌。在过去的12个月中，印度洋的海面温度始终达到0.5-1.0摄氏度，高于平均水平，与正在进行的厄尔尼诺南部振荡相吻合，而本季的季风特别持续，降低了沿海盐度。在拟议的研究期间收集的数据将使我们能够预测南亚海岸线和其他地方的CFP进一步爆发，包括面对全球气候变化。我们的目标是针对未来的CFP事件实施快速响应筛查和管理计划，将有助于确保那些依靠捕鱼作为蛋白质和/或经济资源的人的健康和福祉。