ANTENATAL PHENOBARBITAL AND THE PREVENTION OF NEONATAL INTRACRANIAL HEMORRHAGE

产前苯巴比妥与预防新生儿颅内出血

• 批准号: 2481427
• 金额: $ 1.84万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2481427
• 关键词: brain injury; cerebral hemorrhage; cerebral ischemia /hypoxia; chemoprevention; clinical research; clinical trials; developmental neurobiology; drug screening /evaluation; embryo /fetus chemotherapy; female; human pregnant subject; human subject; human therapy evaluation; infant mortality; neuroprotectants; perinatal; phenobarbital; placebos; premature infant human

This is a randomized, masked, placebo-controlled clinical trial to examine whether phenobarbital (administered antenatally to pregnant women <33 weeks gestation, that are expected to deliver within 24 hours) will reduce the incidence and severity of hemorrhage and/or ischemic brain injury, the mortality rate and incidence of neurodevelopment sequelae in preterm neonates.

这是一项随机、隐蔽、安慰剂对照的临床试验 检查苯巴比妥（孕妇产前服用）是否 <怀孕33周，预计在24小时内分娩）将 减少脑出血和/或缺血的发生率和严重程度 损伤、死亡率和神经发育后遗症的发生率 早产儿。