CEREBRAL AND SYSTEMIC METABOLIC RESPONSES TO IV ADMINISTERED ENDOTOXIN

对静脉注射内毒素的大脑和全身代谢反应

• 批准号: 6246308
• 负责人: Donald Sanderson Prough
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246308
• 关键词: atrial natriuretic peptide; brain metabolism; clinical research; cyclic GMP; endothelin; endotoxins; human subject; intravenous administration; muscle metabolism; muscle proteins; nitrates; nitrites; oxygen consumption; protein metabolism

Will measure cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2) and muscle protein catabolism and serum atrial natruiretic peptide (ANP), endothelin, serum and urinary cGMP, nitrates and nitrites prior to and following administration of E.Coli endotoxin (2-4ng/kg). Hypothesize that IV administered endotoxin will increase CBF, CMRO2 and muscle protein catabolism and will result in increase in above vasodilators. Endotoxin has been previously administered to over 200 volunteers without adverse effects in other research institutions.

将测量脑血流量（CBF）和脑耗氧量 (CMRO2) 和肌肉蛋白分解代谢和血清心房钠 肽 (ANP)、内皮素、血清和尿液 cGMP、硝酸盐和亚硝酸盐 在施用大肠杆菌内毒素（2-4ng/kg）之前和之后。 假设静脉注射内毒素会增加 CBF、CMRO2 和 肌肉蛋白质分解代谢并会导致上述增加 血管扩张剂。 此前已对 200 多名患者注射过内毒素 志愿者对其他研究机构没有不良影响。