NEUROLOGIC ASPECTS OF LYME DISEASE IN NORTH AMERICA

北美莱姆病的神经系统方面

• 批准号: 2037946
• 负责人: PATRICIA K COYLE
• 金额: $ 99.28万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2037946
• 关键词: Lyme disease; central nervous system disorders; neurologic manifestations

Lyme disease is a major emerging infection in the United States, and has become a significant health issue in terms of public awareness, health care costs, and medical practice standards. Neurologic involvement is now recognized as the major morbidity of Lyme disease, but has not been studied in a systematic fashion. This Program Project has assembled an interdisciplinary team of investigators to study neurologic Lyme disease. They will utilize the clinical and laboratory resources of the Lyme Disease Center at Stony Brook. All components of this Program Project are linked by shared methodologies, conceptual frameworks, and common Cores. The three Clinical Projects will provide materials for the Pathogenesis Project: Project 1 will look at the role of host factors (the T cell response) and organism factors (neurotropism, antigenic variation). Project 2 will determine the frequency, correlates, and outcome of central nervous system invasion in early Lyme disease. Project 3 will characterize the neurobehavioral syndromes of chronic Lyme disease. Project 4 will study neurologic Lyme disease in children. The supporting Cores are: A) an Administrative Center Core; B) a Data Management Core; C) a Central Laboratory Core; D) a Neuropsychology Core. The primary scientific goals of this Program Project are 1) to identify and characterize prospectively the neurologic, neuropsychologic, and psychosocial manifestations of Lyme disease in children and adults; and 2) to identify pathogenetic mechanisms involved in neurologic Lyme disease. The secondary goals are 3) to characterize associated cerebrospinal fluid changes; and 4) to identify risk factors for poor outcome. This Program Project will support a structured interdisciplinary effort to study the neurologic aspects of Lyme disease. It will provide information to guide development of rational and cost-effective public health policy for this important infection.

莱姆病是美国的主要新兴感染，并且 就公众意识，健康而成为重大健康问题 护理费用和医疗实践标准。神经系统参与现在已经 被认为是莱姆病的主要发病率，但没有 以系统的方式学习。这个程序项目已经组装了 研究人员研究神经系统疾病的跨学科团队。 他们将利用莱姆的临床和实验室资源 Stony Brook的疾病中心。该程序项目的所有组件都是 通过共享方法，概念框架和共同核心链接。 这三个临床项目将为发病机理提供材料 项目： 项目1将研究宿主因素（T细胞响应）和 生物体因素（神经性，抗原变异）。 项目2将确定中央的频率，相关和结果 莱姆病早期的神经系统入侵。 项目3将表征慢性莱姆的神经行为综合征 疾病。 项目4将研究儿童的神经莱姆病。 支持核心是：a）行政中心核心； b）数据 管理核心； c）中央实验室核心； D）神经心理学核心。 该计划项目的主要科学目标是1）确定 并表征前瞻性的神经系统，神经心理学和 儿童和成人莱姆病的社会心理表现；和2） 确定涉及神经系统疾病的致病机制。 次要目标是3）表征相关的脑脊液 变化； 4）确定结果不良的危险因素。 该计划项目将支持结构化的跨学科工作 研究莱姆病的神经系统方面。它将提供信息 指导发展 这项重要的理性和成本效益的公共卫生政策 感染。