PRECISION IN PATIENT SET-UP AND TARGET LOCALIZATION

患者设置和目标定位的精确度

• 批准号: 6102923
• 负责人: RANDALL K TEN HAKEN
• 金额: --
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6102923
• 关键词: artificial intelligence; behavioral /social science research tag; bioengineering /biomedical engineering; biomedical automation; body movement; brain neoplasms; clinical biomedical equipment; computer assisted patient care; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; diagnosis design /evaluation; digital imaging; head /neck neoplasm; human subject; immobilization of body part; liver neoplasms; lung neoplasms; mathematical model; neoplasm /cancer radiation therapy; neoplasm /cancer radiodiagnosis; patient care planning; patient monitoring device; phantom model; prostate neoplasms; radiation dosage

The overall objective of Project 3 is to quantify, and through improvements, maximize the precision with which target volumes within patients can be localized at the time of treatment. A fundamental goal of conformal radiation therapy is to confine regions of high dose as tightly as possible to target volumes. currently, immobile biologic target volumes need to be expanded to form planning target volumes to account for uncertainties in patient setup between treatments and for organ motion within patients. However, to escalate dose safely beyond current standards, it is necessary to minimize the volume of tissue irradiated. In this project it is hypothesized that through use of improved patient immobilization, real-time diagnostic and megavoltage flat-panel imagers, software to compute corrections for repositioning patients, and a computer controlled treatment machine, it will be possible to accurately and rapidly setup a patient before and/or during each treatment session. It is further hypothesized that, through use of a combination of radio-opaque markers visible on diagnostic and megavoltage studies, the influence of organ motion on target volume localization can be accounted for on a quantitative basis. Thus, Project 3 has two specific aims, which will be addressed through completion of three major subtasks associated with each aim. Aim 1: To develop and implement procedures that enable the reduction of "patient" setup inaccuracies to a level consistent with the precision with which patient position can be measured; with subtasks related to 1a) patient immobilization utilizing improved devices and techniques, 1b) patient localization by means of diagnostic x-ray sources located at the treatment unit in conjunction with innovative composite diagnostic- megavoltage, online flat-panel imagers, and 1c) computer-assisted patient repositioning using a redesigned computer-controlled table top system. Aim 2: To account for "target" motion due to patient organ motion in an otherwise immobilized patient; through subtasks which 2a) determine the stability of inter-treatment patient structure and organ localization, 2b) directly quantify target volume motion in the prostate, liver and lung using implanted radio-opaque markers, and 2c) employ advanced techniques to compensate for organ motion on a daily basis through adjustment of treated volumes or use of physiological gating techniques.

项目3的总体目标是量化 改进，最大化目标体积的精度 患者可以在治疗时被定位。 一个基本目标 共形辐射疗法是将高剂量区域限制为 尽可能紧密地靶向量。 目前，固定生物学 需要扩展目标量以形成计划目标量 在治疗之间的患者设置中解释不确定性 患者内的器官运动。 但是，要安全地升级剂量 当前标准，有必要最大程度地减少组织的体积 辐照。 在这个项目中，假设通过使用 改善患者固定，实时诊断和巨型 平板图像仪，计算重新定位的软件 患者和计算机受控的治疗机将是 可能在和/或期间准确，快速地设置患者 每个治疗课程。 进一步假设，通过使用 在诊断和 巨型研究，器官运动对目标体积的影响 可以根据定量考虑本地化。 因此，项目 3有两个具体目标，将通过完成 每个目标相关联的三个主要子任务。 目标1：发展和 实施程序可以减少“患者”设置 与患者的精度一致的不准确性 可以测量位置；与1A相关的子任务）患者 利用改进的设备和技术的固定化，1B）患者 通过位于 治疗单元与创新的综合诊断 - Megavoltage，在线扁平面板成像仪和1C）计算机辅助患者 使用重新设计的计算机控制的表顶系统重新定位。 目标2：考虑因患者器官运动而导致的“目标”运动 否则固定的患者；通过子任务的子任务2a）确定 治疗间患者结构和器官定位的稳定性， 2b）直接量化前列腺，肝脏和 使用植入的放射性标记和2C）采用高级 每天通过 调整处理的体积或生理门控技术的使用。