CORE--ADHERENCE CORE
核心——坚持核心
基本信息
- 批准号:6236791
- 负责人:
- 金额:$ 36.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-03-01 至 1998-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Colorectal cancer remains the second leading cause of cancer death in
the United States. Recent advances in adjuvant therapy are just
beginning to impact the 5-year survival rates. As a result, early
detection and especially dietary and novel chemopreventive strategies
represent the best hope to significantly decrease the mortality rates
for this disease.
Adherence to clinical trials is an area of increasing concern due in
part to the cost involved in conducting community based clinical trials.
There is increasing interest in identifying those factors that may
affect adherence and are amenable to change, as well as developing
methods to enhance adherence in clinical trials. There is evidence
showing that adherence to long term clinical trials is achievable.
However, the complexity of maintaining long term changes, particularly
dietary changes should be recognized.
The Adherence Core is a service resource which pools expertise and
materials to support the three projects. Subjects in these clinical
studies are 40-80 years old with a history of colorectal adenomatous
polyps. The aims of the core are: 1. to monitor and evaluate adherence
to study procedures, 2. to provide the nurse interveners with
guidelines, consulting and training on promoting participant adherence
to study protocols, 3. to develop strategies to reduce barriers
associated with adherence problems in clinical trials, 4. to develop and
produce materials (e.g. newsletters) and implement procedures (e.g.
general adherence intervention) to enhance participant adherence to
study procedures, 5. to develop, produce and distribute various written
materials educating the participants about potential side effects and
ways to manage them, 6. to optimize subject recruitment strategies to
reduce attrition, 7. to develop instruments to identify behavioral
factors that may influence/predict attrition and/or adherence, and 8.
to educate participants about cancer, its etiology and prevention, with
particular emphasis on colon cancer.
Core outcomes include promotion of adherence, evaluation of the
effectiveness of the General Adherence Enhancement intervention, the
Problem-Solving remedial intervention for non-adherers, the Attrition
Prevention intervention, and generation of qualitative data on problems
experienced by participants in large clinical trials, as well as methods
to solve them.
结直肠癌仍然是癌症死亡的第二大原因
美国。辅助治疗的最新进展只是
开始影响5年生存率。结果,早期
检测,尤其是饮食和新型化学预防策略
代表大大降低死亡率的最大希望
对于这种疾病。
遵守临床试验是越来越关注的领域
进行基于社区的临床试验所涉及的成本的一部分。
确定可能的因素,越来越兴趣
影响依从性,并且可以改变以及发展
在临床试验中提高依从性的方法。有证据
表明遵守长期临床试验是可以实现的。
但是,保持长期变化的复杂性,特别是
应识别饮食变化。
依从性核心是一种汇集专业知识和的服务资源
支持这三个项目的材料。这些临床的受试者
研究有40 - 80年的历史,有结直肠腺瘤的史
息肉。核心的目的是:1。监视和评估依从性
研究程序,2。为护士提供干预者
指南,咨询和培训有关促进参与者的遵守
研究协议,3。制定策略以减少障碍
与临床试验中的依从性问题相关,4。
生产材料(例如新闻通讯)并实施程序(例如
一般依从性干预)以增强参与者的遵守
研究程序,5。开发,生产和分发各种书面
材料对参与者进行有关潜在副作用的教育和
管理它们的方式,6。优化主题招聘策略
减少损耗,7。开发识别行为的工具
可能影响/预测损耗和/或依从性的因素,以及8。
向参与者教育癌症,其病因和预防,并与
特别强调结肠癌。
核心结果包括促进依从性,评估
一般依从性增强干预的有效性,
非顾问的问题解决补救措施,损耗
预防干预,并生成有关问题的定性数据
大型临床试验的参与者以及方法
解决它们。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAN R ATWOOD其他文献
JAN R ATWOOD的其他文献
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{{ truncateString('JAN R ATWOOD', 18)}}的其他基金
NCI DIETARY GUIDELINES IN AFRICAN AMERICAN CHURCHES
非裔美国教会 NCI 饮食指南
- 批准号:
3569268 - 财政年份:1996
- 资助金额:
$ 36.57万 - 项目类别:
NCI DIETARY GUIDELINES IN AFRICAN AMERICAN CHURCHES
非裔美国教会 NCI 饮食指南
- 批准号:
2592635 - 财政年份:1996
- 资助金额:
$ 36.57万 - 项目类别:
FIBER ADHERENCE AND MARKER DEVELOPMENT IN BLACK CHURCHES
黑人教堂的纤维粘附和标记物发展
- 批准号:
2257458 - 财政年份:1993
- 资助金额:
$ 36.57万 - 项目类别:
FIBER ADHERENCE AND MARKER DEVELOPMENT IN BLACK CHURCHES
黑人教堂的纤维粘附和标记物发展
- 批准号:
2257457 - 财政年份:1993
- 资助金额:
$ 36.57万 - 项目类别:
FIBER ADHERENCE AND MARKER DEVELOPMENT IN BLACK CHURCHES
黑人教堂的纤维粘附和标记物发展
- 批准号:
3393018 - 财政年份:1993
- 资助金额:
$ 36.57万 - 项目类别:
ADVANCED NURSE TRAINING: CLINICAL RESEARCH INSTRUMENTS
高级护士培训:临床研究仪器
- 批准号:
3012784 - 财政年份:1986
- 资助金额:
$ 36.57万 - 项目类别:
ADVANCED NURSE EDUCATION: CLINICAL RESEARCH INSTRUMENTS
高级护士教育:临床研究工具
- 批准号:
3012783 - 财政年份:1986
- 资助金额:
$ 36.57万 - 项目类别:
ADVANCED NURSE EDUCATION: CLINICAL RESEARCH INSTRUMENTS
高级护士教育:临床研究工具
- 批准号:
3012781 - 财政年份:1986
- 资助金额:
$ 36.57万 - 项目类别:
相似海外基金
BRIN: URI: TMSR/BEHAVIOR MODIFICATION SUBCORE
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- 批准号:
6973517 - 财政年份:2004
- 资助金额:
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