TREATMENT OF HYPERACTIVE CHILDREN WITH MONOAMINE OXIDASE INHIBITORS

用单胺氧化酶抑制剂治疗多动儿童

• 批准号: 4696312
• 负责人: J L RAPOPORT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696312
• 关键词: MAO inhibitors; attention deficit disorder; behavior test; catecholamines; child (0-11); dextroamphetamine; human subject; human therapy evaluation; male; mental disorder chemotherapy; neurotransmitter metabolism; psychomotor function; psychophysiology; urinalysis

Thirty children with childhood Attention Deficit Disorder (ADD) have been treated with a selective or nonselective MAO inhibitor. The major findings to date are that both clorgyline, a selective MAO-A inhibitor, and tranylcypromine, a nonselective inhibitor, were effective in decreasing hyperactivity and improving attention. There was a significant decrease in urinary MHPG excretion which showed some correlation with behavioral improvement both on MAOIs and on d-amphetamine. However, this decrease in MHPG persisted for several weeks after drugs were stopped while there was immediate behavioral rebound off drug for both amphetamine and for the MAOIs. The study supports alteration of catecholamine metabolism as mediating the effects of stimulant medication. A controlled trial of 1-deprenyl, a selective MAO-B inhibitor, is ongoing.

三十名患有儿童注意力缺陷障碍（ADD）的儿童 用选择性或非选择性 MAO 抑制剂治疗。 主要发现 迄今为止，氯吉林（一种选择性 MAO-A 抑制剂）和 反苯环丙明是一种非选择性抑制剂，可有效减少 多动症和提高注意力。 出现了显着下降 尿液中 MHPG 的排泄与行为有一定的相关性 MAOIs 和 d-苯丙胺的改善。 然而，这种减少 停药后 MHPG 持续数周，而 立即行为反弹苯丙胺和 单胺氧化酶抑制剂。 该研究支持改变儿茶酚胺代谢作为介导 兴奋剂药物的作用。 1-丙炔苯丙胺的对照试验 选择性 MAO-B 抑制剂，正在进行中。