ANTIBODY REPERTOIRE TO STREPTOCOCCAL PNEUMONIAE CAPSULAR POLYSACCHARIDES

肺炎链球菌荚膜多糖抗体库

• 批准号: 6119864
• 负责人: ALEXANDER LUCAS
• 金额: $ 2.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6119864
• 关键词: Streptococcus pneumoniae; antibacterial antibody; antibody formation; bacterial polysaccharides; clinical research; gene expression; human subject; immunoglobulin genes

Streptococcus pneumoniae is an encapsulated bacterial pathogen that causes serious invasive diseases. Considerable evidence indicates that antibodies directed against the capsular polysaccharides mediate protection against pneumococcal infection. However, little is actually known about the clonal and molecular diversity of these important antibody specificities. Our experimental aims are to evaluate the clonality, variable region usage and functional properties of adult antibodies specific for the pneumococcal polysaccharide serotypes 6B, 14 and 23F.

肺炎链球菌是一种封装的细菌病原体，引起 严重的侵入性疾病。 大量证据表明 针对囊囊多糖介导的抗体 防止肺炎球菌感染。 但是，实际上很少 关于这些重要抗体的克隆和分子多样性已知 特殊性。 我们的实验目的是评估克隆性， 成年抗体的可变区域使用和功能特性 特定于肺炎球菌多糖血清型6B，14和23F。