INFANT HEME CATABOLISM AND CARBON MONOXIDE DETECTION

婴儿血红素分解代谢和一氧化碳检测

• 批准号: 6115005
• 负责人: DAVID K STEVENSON
• 金额: $ 4.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115005
• 关键词: bilirubin; biotransformation; blood disorder diagnosis; breath tests; carbon monoxide; clinical research; diagnosis design /evaluation; hemolysis; human subject; infant human (0-1 year); noninvasive diagnosis; patient monitoring device

We continue our development of carbon monoxide (CO)-monitoring technology for laboratory and bedside diagnosis of hemolysis or increased total bilirubin production from other causes. This involves developing and refining instrumentation and techniques for the measurement of excreted CO. These efforts, in cooperation with Natus Medical, Inc. of San Carlos, CA, have resulted in the production of a portable, non-invasive instrument for the bedside monitoring of end- tidal breath CO as an index of bilirubin production for all causes. We evaluated this instrument, formerly known as Baby's Breath, with a CO measuring efficacy of 96%, with neonates in 1996. Recently, the instrument renamed CO-Stat, has been evaluated in a population ranging in age from neonates to adults.

我们继续开发一氧化碳 (CO) 监测 溶血的实验室和床边诊断技术 其他原因导致总胆红素产生增加。这涉及到 开发和完善仪器和技术 测量排出的二氧化碳。这些努力是与内特斯合作的 加利福尼亚州圣卡洛斯的 Medical, Inc. 已生产出一种 便携式、非侵入性仪器，用于终端患者的床边监测 潮气呼吸 CO 作为所有原因产生胆红素的指标。我们 使用 CO 评估了该仪器（以前称为满天星） 1996 年对新生儿测量有效率达 96%。最近， 仪器更名为 CO-Stat，已在不同人群中进行了评估 年龄从新生儿到成人。