LIMBIC SEIZURES & NEUROBEHAVIORAL DEVELOPMENT

边缘系统癫痫发作

• 批准号: 6116307
• 负责人: VIRGINIA M GUNDERSON
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116307
• 关键词: Mammalia; Primates; bioimaging /biomedical imaging; biological products; cognition; growth /development; magnetic resonance imaging; model design /development; nervous system; psychology

The primary goal of this project is to develop a macaque monkey model for complex-partial seizures during the first year of life. The research is important because an estimated 3 5% of children in the United States have at least one seizure before the age of three. There is concern that early seizures may adversely affect cognitive and emotional functioning during childhood. Cranial assemblies are implanted on project animals using stereotaxic surgical techniques. Bicuculline is then microinfused into an area deep within the piriform cortex to induce complex-partial seizures. Each monkey has three seizures within the first months of life and then is assessed for one year on a battery of behavioral, cognitive, and neurological measures. During the past year, we obtained data on nine animals. Our results indicate that seizures can be induced reliably in very young subjects. In addition, prolonged seizures at 3 6 months of age may result in hyperexcitability and subtle cognitive deficits, and may produce brain damage and abnormal EEG activity.

该项目的主要目标是在生命的第一年中开发一种猕猴猴子模型。 这项研究很重要，因为估计在美国三岁之前至少有一次癫痫发作。 人们担心早期癫痫发作可能会对童年期间的认知和情感功能产生不利影响。 使用立体定位手术技术将颅组件植入项目动物上。 然后将双瓜氨酸微灌注到梨状皮层内深处的区域，以诱导复杂的癫痫发作。 每只猴子在生命的头几个月内都有三种癫痫发作，然后在一系列行为，认知和神经系统措施中评估了一年。在过去的一年中，我们获得了有关九只动物的数据。 我们的结果表明，在非常年轻的受试者中可以可靠地诱发癫痫发作。 此外，在3个6个月大的3个月大的癫痫发作可能导致过度兴奋和微妙的认知缺陷，并可能导致脑损伤和异常的脑电图活性。