ALTERATIONS IN SKELETAL MUSCLE STRUCTURE AND FUNCTION IN HIV INFECTION

HIV 感染时骨骼肌结构和功能的改变

• 批准号: 6327658
• 负责人: DONALD P KOTLER
• 金额: $ 5.57万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6327658
• 关键词: AIDS; activation analysis; bioenergetics; body composition; clinical research; diet therapy; dietary proteins; dietary supplements; exercise; human subject; human therapy evaluation; magnetic resonance imaging; malnutrition; muscle function; muscle metabolism; nitrogen balance; nutrition related tag; protein metabolism; quality of life; recombinant proteins; somatotropin; striated muscles

Previous studies documented the frequent occurrence of severe, progressive malnutrition in AIDS. The long-term goal of our studies is to provide an understanding of the pathogenesis of malnutrition in AIDS, a scientific rationale for nutritional therapy, and realistic expectations for the results of such therapy. The specific aims of this proposal are to define the metabolic mechanisms underlying the alterations in body composition that occur as a result of the acquired immune deficiency syndrome, their association with active HIV infection, and their relationship to altered release of cytokines. The centerpiece of these studies will be precise measurements of body composition which will allow precise determination of depletion or repletion. Two approaches will be taken to study the problem. A cohort of asymptomatic, HIV-seropositive men will be studied and followed longitudinally. Estimations are that a subgroup will undergo clinical progression, and that the changes will include body mass depletion. Studies of energy utilization and substrate flux will be performed to determine what type of alterations occur and at what point in the disease. Correlations will be made with serum levels of cytokines. The other approach will be to study malnourished AIDS patients who are undergoing nutritional or antiviral therapy. Recent studies have demonstrated the feasibility of providing nutritional support to these patients and have shown body mass repletion as a result of effective antiviral therapy. Nutritional studies will be performed during the period of repletion and the results correlated with serum levels of cytokines. In later years, the nutritional and metabolic effects of modulating cytokine release will be studied. The ability to mitigate the nutritional consequences of chronic infections in AIDS may be important in reducing the morbidity of such complications.

先前的研究记录了严重、 艾滋病中的进行性营养不良。 我们的长期目标 研究的目的是为了了解发病机制 艾滋病营养不良，营养的科学原理 治疗，以及对此类结果的现实期望 治疗。 该提案的具体目标是定义 身体变化背后的代谢机制 由于获得性免疫而发生的成分 缺乏综合症，它们与活动性艾滋病毒感染的关系， 及其与细胞因子释放改变的关系。 这 这些研究的核心是对身体的精确测量 允许精确测定消耗的组合物 或补充。 将采取两种方法来研究这个问题。 将研究一组无症状、艾滋病毒血清呈阳性的男性 并纵向跟随。 估计是一个子群 将经历临床进展，并且这些变化将 包括体重消耗。 能源利用和能源利用研究 将执行基板通量以确定什么类型 改变发生以及在疾病的哪个阶段发生。 相关性 将用细胞因子的血清水平制成。 另一种方法 将研究正在接受治疗的营养不良艾滋病患者 营养或抗病毒治疗。 最近的研究有 证明了为患者提供营养支持的可行性 这些患者由于以下原因而表现出体重补充 有效的抗病毒治疗。 营养学研究将 补货期间进行的操作及结果 与血清细胞因子水平相关。 在后来的几年里， 调节细胞因子释放的营养和代谢作用 将被研究。 减轻营养不良的能力 艾滋病慢性感染的后果可能很重要 减少此类并发症的发病率。