CORE--METHODS AND ANALYSIS

核心——方法与分析

• 批准号: 6295608
• 负责人: Eve Van Cauter
• 金额: $ 16.94万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-15 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6295608
• 关键词: REM sleep; biomedical equipment resource; biomedical facility; body physical activity; body temperature; chordate locomotion; circadian rhythms; computer data analysis; electroencephalography; electromyography; electrooculography; heart rate; hormone regulation /control mechanism; information systems; monitoring device; neuropsychological tests; photostimulus; sleep; statistics /biometry

The Methods and Analysis Core has two main functions. First, to supply, operate and maintain the specialized equipment used in individual Research projects for monitoring a variety of overt circadian rhythms in rodents and humans, and to implement standard procedures for their computer storage. The Core also explores and validates novel techniques for non-invasive monitoring of overt circadian rhythms in humans and rodents. A second main function is to provide investigators in all five Projects with standard methods for reporting and analyzing temporal profiles of activity, temperature, sleep stages, hormonal levels, and behavioral variables. The Core also explores and validates novel methods for data analysis that are specially suited to the data obtained in the five Projects. The availability of a centralized pool of monitoring equipment prevents equipment duplication and provides the individual investigators with expert assistance for optimal operation and trouble-shooting of the equipment. The availability of standardized procedures for data reporting and analysis enables each investigator to extract as much information as possible from the collected data, and facilitates the integration of individual projects as well as communication between investigators. Standardization of data processing and analysis enables additional comparisons of various study groups across Projects, and thus more information can be derived from the Program Project as a whole than from the sum of each of its components. This core has also enabled the various projects to incorporate a variety of new approaches for recording and analyzing sleep and circadian rhythms. Of particular significance is the development of new approaches over the past 18 months for; 1) the quantitative analysis of circadian pattern fragmentation, 2) the use of a nw device for monitoring alertness under ambulatory conditions, 3) monitoring a range of cognitive functions, and 4) the recording of EEG and EMG waveforms in the hamster using a state-of- he-art system. The use of these and other new approaches developed by t his core will greatly enhance the overall quality and quantity of the data collected in the five projects.

方法和分析核心有两个主要功能。 首先，供应， 操作和维护个人研究中使用的专用设备 用于监测啮齿类动物和动物的各种明显昼夜节律的项目 人类，并为其计算机存储实施标准程序。 该核心还探索和验证非侵入性的新技术 监测人类和啮齿动物的明显昼夜节律。 第二个主要 职能是为所有五个项目的研究人员提供标准 报告和分析活动时间概况的方法， 温度、睡眠阶段、荷尔蒙水平和行为变量。 这 Core 还探索并验证了数据分析的新方法 特别适合在五个项目中获得的数据。 这 集中监控设备池的可用性可以防止 设备重复并为个别调查人员提供专家 协助设备的最佳运行和故障排除。 数据报告和分析标准化程序的可用性 使每个调查员能够从中提取尽可能多的信息 收集的数据，并促进各个项目的整合 以及调查人员之间的沟通。 数据标准化 处理和分析可以对各种研究进行额外比较 跨项目的组，因此可以从 项目计划 项目作为一个整体而不是其各个组成部分的总和。 该核心还使各个项目能够纳入各种 记录和分析睡眠和昼夜节律的新方法。 的 特别重要的是过去新方法的发展 18 个月； 1）昼夜节律模式的定量分析 碎片化，2）使用网络设备来监测警觉性 动态条件，3) 监测一系列认知功能，以及 4）使用state-of-记录仓鼠的脑电图和肌电图波形 艺术系统。 使用这些方法和其他由 t 开发的新方法 他的核心将大大提升数据的整体质量和数量 收集在五个项目中。