CORE--CLINICAL

核心--临床

• 批准号: 6314326
• 负责人: JOHN H GROWDON
• 金额: $ 27.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-16 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314326
• 关键词: Alzheimer's disease; biomedical facility; blood chemistry; brain disorder diagnosis; family genetics; genetic counseling; health education; human subject; human tissue; neuropsychological tests; patient /disease registry; postmortem

A multi-institutional Clinical Core Unit (CCU) was established during the first five years of the Massachusetts ADRC and will continue during years 06 to 10. The three Units are at BAH, MGH, and UMMC. The overall goals of the CCU are to examine, diagnose, and enroll into the ADRC Patient Registry men and women with AD and related dementias , and health control subjects. An associated goal is to characterize the neurological, psychiatric, and neuropsychological features of AD across all stages of illness. The clinical experience at each Unit stimulates and supports new research initiatives, and enhances research productivity. In order to accomplish these goals, subjects are examined at one of the three clinical units; demographic and diagnostic information on all subjects are entered into the joint ADRC central Patient Registry. Standardized data are collected in each Unit on aspects of the clinical history of dementia, features of the neurological examination, results of cognitive tests, and laboratory diagnostic tests. These data are collected in a uniform manner at each of the three Units and maintained in separate but compatible databases. In order to track the course of illness, neurological and psychiatric examinations are repeated every six months; cognitive tests are performed every twelve months. Patients with AD are referred to specific research projects depending upon informed consent and the inclusion and exclusion criteria of each project. Patients with AD and control subjects are encouraged to sign a brain donation form indicating intent for postmortem examination.

在期间建立了多机构的临床核心单位（CCU） 马萨诸塞州ADRC的前五年将继续 06至10年。这三个单元在BAH，MGH和UMMC。 总体 CCU的目标是检查，诊断和注册ADRC 患者注册表有AD和相关痴呆症的男性和女性，以及 健康控制对象。一个相关的目标是表征 广告的神经，精神病和神经心理学特征 疾病的所有阶段。 每个单元的临床经验刺激 并支持新的研究计划，并增强研究 生产率。 为了实现这些目标，对主题进行了检查 三个临床单位；所有人的人口统计和诊断信息 受试者进入联合ADRC中央患者注册表。 在临床方面收集标准化数据 痴呆史，神经学检查的特征，结果 认知测试和实验室诊断测试。 这些数据是 以统一的方式在三个单元中以统一的方式收集 在单独但兼容的数据库中。 为了跟踪 每次重复疾病，神经和精神病检查 六个月；认知测试每十二个月进行一次。 广告患者根据特定的研究项目的转诊 根据知情同意以及每个人的包含和排除标准 项目。 鼓励患有AD和对照对象的患者签署 脑捐赠形式，指示验尸检查的目的。