BIOACTIVE AGENTS FROM DRYLAND BIODIVERSITY OF LATIN AMER

来自拉丁美洲旱地生物多样性的生物活性剂

• 批准号: 6318747
• 负责人: BARBARA N TIMMERMANN
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6318747
• 关键词: Mexico; South America; alternative medicine; antibacterial agents; antifungal agents; antiinflammatory agents; antineoplastics; antiviral agents; arid climate; bioassay; cardiovascular agents; computer system design /evaluation; cooperative study; drug design /synthesis /production; drug screening /evaluation; field study; herbicides; information dissemination; information systems; insecticides; international cooperation; medicinal plants; microorganism classification; microorganism population study; plant ecology; plant extracts; publications; training; tropical medicine; workshop

DESCRIPTION: (Applicant's Description) The long term objectives of the Latin American ICBG are to discover and develop biologically active agents from natural sources to promote sustained economic growth while conserving natural resources from which these products are derived. This program seeks to identify new therapeutic agents that are candidates or can serve as leads in the treatment of infectious diseases, cardiovascular and central nervous system disorders, cancer and inflammation, women's health as well as illnesses prevalent in developing countries. This ICBG project also searches for leads for agricultural crop protection (herbicides, fungicides and insecticides) and veterinary medicine. Studies will include plants and microbes mainly from dryland ecosystems in Argentina, Chile and Mexico. The specific aims are to: 1) identify plants and their populations that are utilized in local health practices or show some mechanism of resistance to natural predators; 2) isolate and identify unusual populations of microbes from selected plant communities; 3) evaluate the biological activities of these plants and microbes; 4) isolate and chemically identify the active compounds in these natural resources and promote their use for human, animal or agricultural benefit; 5) return benefits (derived from these resources) to the local communities in order to promote conservation of the plants and their habitat as well as improve the life of the communities; 6) develop a plant catalog database and its representative Web site; 7) publish a newsletter in print and online; 8) foster academic advancement and capacity building in each host country; 9) work on ecological restoration projects and establishment of regional botanical gardens as part of conservation activities; 10) aid host governments towards legislation for conservation and facilitation of access to biological resources, and 11) organize periodical workshops for the general public, teachers and the academic community. The successful discovery of rare, novel therapeutic agents and agrochemicals depends upon the rapid evaluation of large numbers of chemically diverse compounds in targeted, high volume detection systems. This ICBG has the capabilities to reach the proposed objectives through the application of the latest developments in spectroscopic and spectrometric methods as well as in robotic, micro-instrumentation and computerization.

描述：（申请人的描述） 拉丁美洲洲际弹道的长期目标是发现和 开发从天然来源的生物活性剂以促进持续 经济增长，同时保存这些产品的自然资源 得出。 该计划旨在确定新的治疗剂 候选人或可以作为治疗传染病的铅， 心血管和中枢神经系统疾病，癌症和 炎症，妇女健康以及疾病的发展 国家。 这个洲际弹道导弹的项目还在寻找农作物的潜在客户 保护（除草剂，杀菌剂和杀虫剂）和兽医 药品。 研究将包括主要来自旱地的植物和微生物 阿根廷，智利和墨西哥的生态系统。 具体目的是：1） 识别在当地健康中使用的植物及其种群 实践或表现出对天然捕食者的抵抗的某种机制； 2） 分离并从选定的植物中鉴定微生物的异常种群 社区； 3）评估这些植物的生物学活动和 微生物； 4）分离和化学鉴定这些活性化合物 自然资源并促进对人，动物或农业的使用 益处; 5）返回利益（从这些资源衍生）到本地 为了促进植物及其栖息地的保护社区 以及改善社区的生活； 6）开发植物目录 数据库及其代表网站； 7）在印刷中发布新闻通讯 和在线； 8）促进每个人的学术发展和能力建设 东道国; 9）从事生态恢复项目和机构的工作 作为保护活动的一部分区域植物园； 10）援助 东道国政府采取立法，以保护和促进 获取生物资源，以及11）组织定期研讨会 公众，教师和学术界。 成功 发现稀有的新型治疗剂和农业化学的发现取决于 对大量化学化合物的快速评估 有针对性的高量检测系统。 这个洲际弹道导弹具有 通过最新的应用达到提议的目标 光谱和光谱方法的发展以及 机器人，微启示和计算机化。