LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS

青少年的生活方式、肥胖和心血管健康

• 批准号: 6197518
• 负责人: Bernard Gutin
• 金额: $ 61.92万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6197518
• 关键词: adolescence (12-20); behavioral /social science research tag; body composition; cardiovascular disorder; cardiovascular function; cardiovascular stress test; clinical research; diet; disease /disorder proneness /risk; exercise; gender difference; health behavior; human subject; lifestyle; magnetic resonance imaging; obesity; photon absorptiometry; racial /ethnic difference; socioeconomics

DESCRIPTION: (Adapted from the Investigator's Abstract) Rationale and long-term objectives: Adult studies have shown that adiposity, especially visceral adipose tissue (VAI), and cardiovascular (CV) fitness are key links between lifestyle factors like diet and exercise on one hand, and CV disease on the other. However, very little is known about these links during the juvenile years, when the processes leading to CV disease are at an early stage of development. The specific aims are as follow: (1) to determine the relations of free-living diet and exercise to total body percent fat ( percentBF), VAT and CV fitness in black and white boys and girls of varying SES. (2) to determine the relations of fatness and fitness to different CVD risk factors. Design and methods: (1) Recruit 800 15 to 18 year olds, 200 in each ethnicity and gender subgroup. (2) Assess diet with seven 24-hour recalls, and exercise with two seven-day recalls and heart rate monitoring. (3) Measure percent body fat with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging and CV fitness with a multi-stage treadmill test. (4) Measure major fatness- and fitness-related CV disease risk factors (e.g., total cholesterol:HDL cholesterol ratio, insulin, systolic blood pressure, left ventricular mass indexed to height, fibrinogen). (5) Conduct multivariate and univariate analyses to determine relationships. Health relatedness: The investigators state that the provided by this project will assist in the formulation of effective lifestyle interventions targeted to specific demographic groups for primary prevention of CVD, starting early in life when the foundations for adult disease are being laid.

描述：（根据调查员的摘要改编）原理和长期 目标：成人研究表明肥胖，尤其是内脏 脂肪组织（VAI）和心血管（CV）健身是关键联系 一方面的生活方式因素，例如饮食和运动，以及在 其他。但是，对少年期间的这些链接知之甚少 几年，当导致简历疾病的过程处于早期阶段 发展。 具体目的如下：（1）确定自由生活的关系 饮食和锻炼总体百分比脂肪（百分比），增值税和简历健身 黑人和白人男孩和不同SES的女孩。 （2）确定关系 对不同CVD风险因素的肥胖和健身。 设计和方法：（1）招募800 15至18岁的年轻人，每个种族中有200 和性别子组。 （2）用七个24小时召回和运动评估饮食 进行了两次为期7天的召回和心率监测。 （3）衡量身体百分比 带有双能量X射线吸收法的脂肪，带有磁共振成像的增值税 和CV健身，并进行多阶段跑步机测试。 （4）测量主要脂肪 - 和与健身相关的CV疾病危险因素（例如，总胆固醇：HDL 胆固醇比，胰岛素，收缩压，左心室肿块 索引至高度，纤维蛋白原）。 （5）进行多元和单变量 分析以确定关系。 健康相关性：调查人员指出，该项目提供的 将协助制定针对的有效生活方式干预措施 特定的人群组以初级预防CVD，从早期开始 奠定成人疾病基础的生活。