NURSING THERAPY--ATTENTIONAL FATIQUE IN CANCER PATIENTS

护理治疗——癌症患者的注意力疲劳

• 批准号: 6186841
• 负责人: BERNADINE E. CIMPRICH
• 金额: $ 8.56万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6186841
• 关键词: attention; behavioral /social science research tag; breast neoplasms; clinical research; cognition; environment; fatigue; female; functional ability; human subject; human therapy evaluation; longitudinal human study; neoplasm /cancer therapy; nursing intervention; psychological aspect of cancer; psychological stressor; psychometrics; relaxation

DESCRIPTION: (Adapted from investigator's abstract) The proposed project evaluates the efficacy of a new intervention for attentional and functional restoration in women newly diagnosed with breast cancer. Preliminary data demonstrated that breast cancer patients manifested an attentional fatigue with reduced capacity to direct attention (CDA) during the three months following surgery and that such directed attention fatigue (DAF) could be ameliorated by a theoretically-based intervention involving regular exposure to natural restorative environment. Building on these findings, the project's specific aims are to determine whether: (a) a restorative environmental intervention can prevent or minimize losses in CDA over a longer period during and following breast cancer treatment; (b) any differences exist in the pattern and severity of DAF and the efficacy of the experimental intervention by type of breast cancer; (c) DAF produces an impairment in overall cognitive functioning; and (d) DAF is associated with poorer functional adjustment over time. Two hundred women, newly diagnosed with Stage I or II breast cancer, who will be treated either with breast conserving surgery plus radiation or mastectomy plus adjuvant chemotherapy, will be randomly assigned to receive usual care or an experimental intervention; a home-based program of 120 minutes per week of exposure to a natural restorative environment. Subjects will be assessed at five time points: before surgery (pre-intervention), about 2 weeks post-surgery, and at 3, 6, and 9 months post-surgery. The efficacy of the intervention over time on parameters of DAF, i. e., measures of the capacity to inhibit competing stimuli, will be evaluated using repeated measures ANOVA. Repeated measures ANOVA will also be used to compare the efficacy of the intervention within and between breast cancer treatment subgroups and any variations in pattern and severity of DAF. The ability to predict cognitive impairment in measures of short-term memory, higher level cognitive activities and cognitive control by DAF parameters will be tested using correlational and linear panel analyses. Finally, the associations between parameters of DAF and indicators of poorer functional adjustment, i.e. functional status, psychological distress, symptom distress, capacity to exert physical effort, and selected biological indices, will be examined. The ultimate aim of the research is to develop a theoretically based, low-cost intervention to restore attention and improve overall functioning in women treated for breast cancer.

描述：（根据调查员的摘要改编）拟议项目 评估新干预对注意力和功能的疗效 刚诊断为乳腺癌的女性的恢复。 初步数据 证明乳腺癌患者表现出注意力疲劳 在三个月内直接注意的能力降低（CDA） 手术后，这种定向的注意疲劳（DAF）可能是 由理论上的干预措施改善，涉及定期暴露 到自然恢复环境。 在这些发现的基础上， 项目的具体目的是确定是否：（a）修复 环境干预可以预防或最大程度地减少CDA的损失 乳腺癌治疗期间和之后的更长时期； （b）任何 DAF的模式和严重性存在差异以及 乳腺癌类型的实验干预； （c）DAF产生 总体认知功能的损害； （d）DAF与 随着时间的推移，功能调整较差。 200名妇女，新诊断 与第一阶段或II乳腺癌，他们将接受乳房治疗 保存手术加辐射或乳房切除术以及辅助化疗， 将随机分配接受常规护理或实验性 干涉;一个家庭计划，每周120分钟 自然恢复环境。 受试者将在五次进行评估 点：手术前（干预前），手术后大约2周， 手术后3、6和9个月。 干预的功效 DAF参数上的时间，i。例如，抑制能力的度量 竞争刺激将使用重复测量方差分析评估。 重复测量方差分析也将用于比较 乳腺癌治疗中和之间的干预亚组和任何 DAF模式和严重程度的变化。 预测认知的能力 impairment in measures of short-term memory, higher level cognitive 将使用DAF参数进行活动和认知控制 相关和线性面板分析。 最后，关联 DAF的参数和功能调整较差的指标，即 功能状况，心理困扰，症状困扰，能力 将检查身体上的努力和选定的生物指数。 该研究的最终目的是开发理论上的， 低成本干预以恢复注意力并提高整体功能 在接受乳腺癌治疗的妇女中。