AGE RELATED GEOGRAPHIC ATROPHY

与年龄相关的地理萎缩

基本信息

批准号：
6207798
负责人：
JANET S SUNNESS
金额：
$ 14.6万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-03-01 至 2000-09-29
项目状态：
已结题

项目摘要

Geographic atrophy of the retinal pigment epithelium is an inadequately studied form of advanced age-related macular degeneration. Geographic atrophy is responsible for a significant portion of the moderate and severe central visual loss present in the elderly population, but its evolution and progression over time is not understood. The long-term objective of the proposed study is to learn more about the natural course of geographic atrophy, and to determine whether visual function measures and funduscopic evaluation may help to predict and monitor spread. The first aim of this study is to characterize the evolution of geographic atrophy by using the photographic archives of the Wilmer Institute, and by prospectively studying fundus changes in subjects recruited for this study. Of critical interest is the rate of spread of atrophy toward the foveal center, and how this varies as a function of size of the atrophic region(s) and distance from the fovea. The second aim is to determine whether the direction or rate of spread can be predicted by visual function characteristics and funduscopic characteristics of the surrounding regions. The third aim is to study how dependent the loss of foveal function is upon the contiguous spread of atrophy. That is, if the spread could be halted, would the fovea remain relatively intact, or would it in and of itself develop atrophy with resultant visual loss? The fourth aim is to determine whether the likelihood and site of development of geographic atrophy can be predicted in fellow eyes of patients with unilateral geographic atrophy. Currently geographic atrophy is untreatable. It is anticipated that this study will identify those visual function and funduscopic characteristics important for following progression of this disorder, and thereby provide information needed for evaluating any proposed treatment regimen.

视网膜色素上皮的地理萎缩是不足的研究了与年龄相关的黄斑变性的形式。地理萎缩造成了中等和中等的一部分老年人口中存在严重的中央视觉损失，但随着时间的流逝，进化和进展尚不清楚。长期拟议的研究的目的是了解有关自然的更多信息地理萎缩过程，并确定视觉功能是否措施和基础评估可能有助于预测和监测传播。这项研究的第一个目的是表征通过使用威尔默的摄影档案的地理萎缩研究所，并通过前瞻性研究主题的底部变化招募了这项研究。关键的关注是传播率朝动凹中心的萎缩，以及它如何随着萎缩区域的大小和距离中央凹的距离。第二个目的是确定利差方向或速率是否可以通过视觉函数特征和基础上的预测周围地区的特征。第三个目的是学习中央凹功能的损失如何取决于连续的扩散萎缩。也就是说，如果可以停止蔓延，则该中央凹是否会保持相对完整，或者本身会发展萎缩导致视觉损失？第四个目标是确定是否地理萎缩的可能性和发展部位可以是单方面地理萎缩患者的眼睛预测。目前，地理萎缩是无法治疗的。预计这项研究将识别那些视觉功能和底面对于遵循这种疾病进展至关重要的特征，因此提供了评估任何提议所需的信息治疗方案。