ANDROGEN DEPENDENT ANGIOGENESIS IN THE PROSTATE

前列腺中雄激素依赖性血管生成

• 批准号: 6177823
• 负责人: DAVID A MOSCATELLI
• 金额: $ 23.33万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-28 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6177823
• 关键词: androgens; angiogenesis; animal genetic material tag; apoptosis; athymic mouse; benign prostate hyperplasia; developmental genetics; gene induction /repression; hormone regulation /control mechanism; human tissue; male castration; prostate; tissue /cell culture; vascular endothelial growth factors; vascular endothelium

DESCRIPTION (Adapted from the Applicant's Abstract): In this second revised submission, the applicant details studies to examine mechanisms regulating vascularization of the normal prostate. Based on consideration that: (a) prostatic vascularity is androgen modulated, and (b) endothelial cells lack androgen receptors, the applicant proposes that androgen-mediated prostatic angiogenesis is indirectly effected by the potent angiogenic factor, vascular endothelial growth factor (VEGF). It is believed that expression of VEGF is androgen-modulated in non-endothelial prostatic cells.

描述（根据申请人的摘要改编）：在第二个修订中 提交，申请人的详细研究研究以检查调节的机制 正常前列腺的血管化。 基于：（a） 前列腺血管是雄激素调节的，（b）内皮细胞缺乏 申请人提出雄激素受体，提出雄激素介导的前列腺 血管生成是由有效的血管生成因子间接影响的 血管内皮生长因子（VEGF）。 相信表达 在非内皮前列腺细胞中进行了雄激素调节的VEGF。