MEASUREMENT OF ADAPTIVE STYLE IN CHILDREN WITH CANCER

癌症儿童适应性风格的测量

• 批准号: 6094522
• 负责人: Sean Phipps
• 金额: $ 16.02万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6094522
• 关键词: adolescence (12-20); behavioral /social science research tag; blood pressure; child psychology; clinical research; cortisol; early experience; heart rate; human subject; longitudinal human study; middle childhood (6-11); muscle tension; pediatric neoplasm /cancer; psychological adaptation; psychological aspect of cancer; repression; stress

Description (adapted from investigator's abstract): The construct of adaptive style provides a heuristic model for understanding the frequently reported findings of lower self-reports of psychological distress in children with cancer, in comparison to healthy children. Assessment of adaptive style allows for differentiation between truly low anxious individuals, who accurately report low levels of distress, and repressors, who maladaptively avoid the perception of negative affect of distress. In adults, repressive adaptation has been associated with altered patterns of physiological response to stress, and is related to numerous adverse health outcomes. Such relationships have not yet been studied in children. Recent studies have demonstrated a significantly higher incidence of repressors in children with cancer relative to healthy children, which accounts, in part, for the lower levels of distress by self-report in these children. Given the higher incidence of repressive adaptation in children with cancer, adaptive style may be a particularly important predictor of health outcomes in this population. The present proposal aims to improve measurement of adaptive style in children by combining self-report and psychophysiological assessment techniques, while examining the clinical significance of adaptive style in children undergoing treatment for cancer. The specific aims of the project are: 1) To determine the physiological concomitants of adaptive style in healthy children and children with cancer; 2) To assess the concordance in measurement of adaptive style by self-report and physiological indices; and 3) to determine the relationship of adaptive style to tolerance of anti-cancer therapy in children with recently diagnosed malignancies. These aims will be accomplished through two related studies. Study 1 will use a two group, case control design, pairing children who have completed treatment for cancer with healthy children matched on age, race, and gender. Participants will complete a battery of self report measures assessing adaptive style and then undergo physiological monitoring (heart rate, blood pressure, muscle tension, skin conductance, salivary cortisol) in a laboratory stress assessment task. Study 2 utilizes a single group, short term longitudinal design to determine the significance of adaptive style as a predictor of tolerance to anti-cancer therapy in terms of treatment side effects, acute toxicities and medical complications. Newly diagnosed pediatric cancer patients will undergo an identical procedure of self-report measures, stress tasks, and physiological assessment to assess adaptive style, and then be followed prospectively for 6 months while on active therapy. This study will advance knowledge regarding adaptive style in children, which can help to improve identification of truly distressed and non-distressed children, as well as those who may be at high risk for adverse healthy outcomes as a function of adaptive style.

描述（根据调查员的摘要改编）：适应性的构造 样式提供了一种启发式模型，以理解经常报告的 患有儿童心理困扰的自我报告的结果 与健康的孩子相比，癌症。自适应风格的评估允许 对于真正低焦虑的人的区分，他们准确地 报告低水平的痛苦和压抑者，他们不适合避免 对遇难的负面影响的看法。在成年人中，抑制作用适应 与对压力的生理反应的改变有关，以及 与许多不良健康结果有关。这种关系尚未 在儿童中被研究。最近的研究表明 相对于健康的癌症儿童的阻遏物发病率较高 儿童，部分原因是较低的困扰级别 在这些孩子中自我报告。考虑到更高的抑郁症发生率 适应癌症儿童，自适应风格可能是一个特别的 该人群中健康结果的重要预测指标。目前的提议 旨在通过合并来提高儿童适应风格的测量 自我报告和心理生理评估技术，同时检查 在接受治疗的儿童适应性样式的临床意义 癌症。该项目的具体目的是：1）确定生理 健康儿童和癌症儿童的适应性风格的伴随； 2） 通过自我报告和 生理指标； 3）确定自适应风格的关系 在最近诊断的儿童中耐受抗癌治疗 恶性肿瘤。这些目标将通过两项相关研究来实现。 研究1将使用两组，案例控制设计，配对的孩子 与健康儿童的癌症治疗与年龄，种族和 性别。参与者将完成一系列自我报告措施评估 自适应样式，然后接受生理监测（心率，血液 在实验室中的压力，肌肉张力，皮肤电导，唾液皮质醇） 压力评估任务。研究2使用一组，短期 纵向设计以确定自适应风格的重要性 在治疗方面的耐受性耐受性预测指标 影响，急性毒性和医疗并发症。新诊断的小儿 癌症患者将接受相同的自我报告措施的程序， 压力任务和生理评估，以评估适应性风格，然后 在主动治疗时，前瞻性持续6个月。这项研究会 关于儿童适应风格的提前知识，这可以帮助 改善对真正苦恼和未分配的孩子的识别 作为那些可能有不良健康结果的高风险的人 自适应风格。