DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM

药物依赖性临床研究计划

• 批准号: 6174894
• 负责人: Reese T. Jones
• 金额: $ 48.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6174894
• 关键词: administrative personnel; analytical chemistry; biomedical facility; chemical synthesis; clinical research; cocaine; drug addiction; human data; methamphetamine; nicotine; statistical service /center; technical writing

We propose a P30 center to enhance and extend the effectiveness of currently funded human laboratory and treatment clinical research on the clinical pharmacology and pharmacotherapy of abused drugs. Our approach is multi-disciplinary, including investigators from psychiatry, psychopharmacology, clinical psychology, neurology, general internal medicine and clinical pharmacology, toxicology, dermatology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. The research focuses on the clinical pharmacology and pharmacotherapy of stimulant drugs; cocaine, methamphetamine, and nicotine. Individually funded projects enhanced the center's core resources include studies of the pharmacokinetics and pharmacodynamics of nicotine, nicotine kinetics in twin studies to investigate genetic susceptibility to nicotine addiction, pharmacokinetics of cocaine and methamphetamine in skin and hair with particular attention to understanding mechanisms for individual differences, innovative pharmacotherapies for cocaine addiction, and isradipine pharmacotherapy for methamphetamine addiction. The research involves only human subjects. This application requests support for a shared administrative and laboratory research infrastructure. Our aims are: 91) To provide a state-of-the-art analytical and synthetic chemistry resource for collaborative projects. (2) To provide administrative coordination and a resource for preparation of manuscripts, IRB submissions, grant applications fro data processing, and report preparation, coordination of research seminars, and other teaching and communication activities, grant management, and to carry out other administrative services required by the research teams. (3) To provide statistical services, particularly advice on study design and data analysis. The aim of the P30 center is to provide a facility with adequate administrative and scientific resources with stability of support and continuity as individually funded scientific projects change and evolve over time. This facility will be a cost-effective shared resource and will foster a synergistic approach and enhanced funded research to further our understanding of the clinical pharmacology of human psychoactive drug use, its health consequences and its management.

我们提出了一个P30中心，以增强和扩展有关滥用药物的临床药理学和药物治疗的当前资助的人类实验室和治疗临床研究的有效性。我们的方法是多学科的，包括精神病学，心理药理学，临床心理学，神经病学，通用内科和临床药理学，毒理学，皮肤病学，遗传学，儿科，药房，有机物，药物，药物和分析化学和统计学的研究者。该研究的重点是刺激药物的临床药理学和药物疗法。可卡因，甲基苯丙胺和尼古丁。单独资助的项目增强了该中心的核心资源包括对双胞胎研究中尼古丁的药代动力学和药效学，尼古丁动力学的研究，以研究对尼古丁成瘾的遗传易感性，可卡因的药代动力学，皮肤和甲基苯丙胺在皮肤和头发上的药代动力学，特别注意对个性差异，对个性差异的关注，可卡因成瘾的创新药物治疗和甲基苯丙胺成瘾的Isradipine药物疗法。该研究仅涉及人类受试者。该应用程序要求支持共享的行政和实验室研究基础设施。我们的目标是：91）为协作项目提供最先进的分析和合成化学资源。 （2）提供行政协调和资源，以准备手稿，IRB提交，赠款申请，通过数据处理，报告准备，研究研讨会的协调以及其他教学和交流活动，赠款管理，并进行其他行政服务研究团队要求。 （3）提供统计服务，特别是有关研究设计和数据分析的建议。 P30中心的目的是为设施提供足够的行政和科学资源，并稳定支持和连续性，因为个人资助的科学项目随着时间的流逝而改变和发展。该设施将是一种具有成本效益的共享资源，并将促进一种协同的方法，并增强了资助的研究，以进一步了解人类精神药物使用，其健康后果及其管理的临床药理学。