A rapid saliva test to assess protection against disease and monitor vaccination in low-middle income countries
快速唾液测试,用于评估中低收入国家的疾病保护并监测疫苗接种情况
基本信息
- 批准号:MR/Y019318/1
- 负责人:
- 金额:$ 142.65万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Live saving childhood vaccinations fail to reach ~25 million children worldwide. As a result of the COVID-19 pandemic, many people across the world have missed out on essential vaccines, increasing those at risk of serious disease. Tetanus is a bacterial infection with a high death rate but is preventable with vaccination. Tetanus is one of the key vaccines given routinely but the amount of people receiving this vaccine has slipped back to lower levels seen many years ago. Eliminating tetanus has been an aim for over 20 years. This has been achieved in many countries but in low-middle income countries this disease is still a problem and continues to cause unnecessary deaths every year. It is important to monitor vaccination and understand how many people are protected against disease, but this can be challenging to do directly. Having information on immunity (protection from disease) is helpful to understand how well vaccination plans are working and help find individuals who are unprotected and need vaccination. However, testing immunity currently requires blood samples. Testing immunity in blood can be expensive and some countries are unable to do it. Also, not everyone wishes to have blood taken and taking blood from children is not desirable. We will develop a low-cost test that enables immunity to be tested easily, quickly, and without taking blood. The test uses saliva and is a lateral flow test, a type of test which is now well known to the public. The test shows if a person is/is not protected against tetanus within 15 minutes. If a person is unprotected against tetanus, they are also likely missing protection against other serious diseases and have not received all recommended vaccinations. The test can be used anywhere (outreach, community, clinic, hospital) and can improve access to immunity testing for those who currently are unable to do so. In this project we will develop our saliva test with help from an expert company. We will spend time trying various materials and ways to build the test to get the best invention. We are aiming to use as little plastic as possible in our test. We will also find out the easiest way to collect saliva to run the test. Then we will run lots of saliva samples on our test in a laboratory to check how well the test works. If the test works as well, it will then be sent to be included in a study in Malawi (a low-income country in Africa). In this study, we will see how well our test works in real-life and find out how suitable local people find the test. If successful, after the project we intend to try out the test in other countries to measure immunity among different communities, to improve vaccination monitoring and planning.
全球约 2500 万儿童未能获得挽救生命的儿童疫苗接种。由于 COVID-19 大流行,世界各地许多人错过了基本疫苗,从而增加了患严重疾病的风险。破伤风是一种死亡率很高的细菌感染,但可以通过疫苗接种来预防。破伤风是常规接种的主要疫苗之一,但接受这种疫苗的人数已回落至多年前的较低水平。消除破伤风一直是 20 多年来的目标。许多国家已经实现了这一目标,但在中低收入国家,这种疾病仍然是一个问题,并且每年继续造成不必要的死亡。监测疫苗接种并了解有多少人免受疾病侵害很重要,但这可能很难直接做到。掌握有关免疫(预防疾病)的信息有助于了解疫苗接种计划的效果,并帮助找到未受保护且需要疫苗接种的个人。然而,目前测试免疫力需要血液样本。测试血液中的免疫力可能会很昂贵,而且一些国家无法做到这一点。此外,并不是每个人都希望抽血,从儿童身上抽血也是不可取的。我们将开发一种低成本的测试方法,使免疫测试能够轻松、快速且无需抽血。该测试使用唾液,属于侧向流动测试,是现在为公众所熟知的一种测试。该测试可在 15 分钟内显示一个人是否能够预防破伤风。如果一个人没有针对破伤风的保护,他们也可能缺乏针对其他严重疾病的保护,并且没有接受所有推荐的疫苗接种。该测试可以在任何地方(外展、社区、诊所、医院)使用,并且可以改善那些目前无法进行免疫测试的人的获得机会。在这个项目中,我们将在专家公司的帮助下开发唾液测试。我们将花时间尝试各种材料和方法来构建测试以获得最好的发明。我们的目标是在测试中使用尽可能少的塑料。我们还将找出收集唾液进行测试的最简单方法。然后我们将在实验室进行大量唾液样本测试,以检查测试效果如何。如果测试顺利,它将被送往马拉维(非洲低收入国家)的一项研究。在这项研究中,我们将了解我们的测试在现实生活中的效果如何,并了解当地人如何适合该测试。如果成功,项目结束后我们打算在其他国家尝试该测试,以测量不同社区之间的免疫力,以改善疫苗接种监测和规划。
项目成果
期刊论文数量(0)
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Jennifer Heaney其他文献
Effects of aerobic and resistance exercise for 9 months on serum free light chains in type 2 diabetes
9个月有氧运动和抗阻运动对2型糖尿病血清游离轻链的影响
- DOI:
10.3389/fphys.2024.1328470 - 发表时间:
2024-04-25 - 期刊:
- 影响因子:4
- 作者:
Youyoung Kim;John P. Campbell;Neil M. Johannsen;Timothy S Church;Eunhan Cho;Jennifer Heaney;G. Spielmann - 通讯作者:
G. Spielmann
Jennifer Heaney的其他文献
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