TGF-B RECEPTOR ALTERATIONS AND PANCREAS CANCER

TGF-B 受体改变与胰腺癌

• 批准号: 6172812
• 负责人: James W. Freeman
• 金额: $ 22.44万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6172812
• 关键词: athymic mouse; gene induction /repression; growth factor receptors; guanine nucleotide binding protein; human genetic material tag; human tissue; mutant; neoplasm /cancer genetics; neoplastic process; nucleic acid sequence; pancreas neoplasms; protein structure function; receptor expression; transforming growth factors; tumor suppressor genes

DESCRIPTION: The long term goal of this study is to determine the role of TGFbeta RII receptor (RII) in pancreatic cancer. Loss of response to TGFbeta appears common to pancreatic cancer, which is often caused by a loss of the RII gene expression. The hypothesis to be tested in this revised application is that the loss of RII expression is caused by ras-mediated down regulation of the gene and that lack of a functional RII receptor plays an important role in the tumorigenic properties of pancreatic cancers. The specific aims are 1) Determine the mechanism by which oncogenic ras inhibits RII expression and/or causes resistance to growth inhibition by TGFbeta, and 2) Determine the biological role of RII in tumor progression in ras-mutated pancreatic cancer cells.

描述：本研究的长期目标是确定 胰腺癌中的TGFBETA RII受体（RII）。 失去对 TGFBETA似乎是胰腺癌常见的，这通常是由损失引起的 RII基因表达。 在此修订后要检验的假设 应用是RII表达的损失是由RAS介导的 下调基因和缺乏功能性RII受体播放 在胰腺癌的致瘤特性中的重要作用。 这 具体目的是1）确定致癌Ras抑制的机制 RII表达和/或引起TGFBETA抑制生长抑制的能力，而 2）确定RII在RAS突变中肿瘤进展中的生物学作用 胰腺癌细胞。