IGG RECEPTOR ISOFORMS AND NEONATAL INFECTIONS

IGG 受体异构体和新生儿感染

• 批准号: 6182577
• 负责人: JOSEPH B PHILIPS
• 金额: $ 7.18万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-10 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6182577
• 关键词: CD antigens; bacterial disease; blood chemistry; clinical research; cytokine; disease /disorder proneness /risk; genetic markers; human subject; immunoglobulin G; neutrophil; newborn human (0-6 weeks); polymerase chain reaction; population genetics; premature infant human; protein isoforms

DESCRIPTION: (Adapted from applicant's abstract) The hypothesis that will be tested in prospective studies with all available patients plus controls from two neonatal intensive care units is that the low responding FcgammaR genotypes (FcgammaRIIA, FcgammaRIIIA, FcgammaRIIIB) are more frequent in infants with late onset sepsis. The outcome will be to estimate the risk factor for late onset sepsis derived from expression of FcgammaR gentoype.

描述：（改编自申请人的摘要） 在所有可用患者的前瞻性研究中进行了测试以及 两个新生儿重症监护病房是低反应的FCGAMMAR基因型 （fcgammariia，fcgammariiia，fcgammariiib）在婴儿中更常见 败血症晚期。结果将是估计迟到的危险因素 败血症源自Fcgammar Gentoype的表达。