Bench, Bedside, Business, and Beyond: innovative solutions for AMR diagnostics

实验室、床边、商业及其他：AMR 诊断的创新解决方案

• 批准号: MR/X036936/1
• 负责人: Leonid Chindelevitch
• 金额: $ 5.62万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX036936%2F1
• 关键词: Bench; Bedside; Business; Beyond; innovative

The network, B2B2B AMRDx, brings together a diverse group of researchers from universities (bench), hospitals (bedside), for-profits (business), governments and nonprofits (beyond), to tackle some of these challenges. We have expertise in human, animal, and environmental AMR, and come from 20 different countries. The networks goals are as follows.First, the network creates a comprehensive online AMR Diagnostics Developer Directory (ADDD) to facilitate exchange of ideas in the field. Second, the network extends the JPIAMR Seq4AMR Virtual Benchmarking Platform (VBP) to allow diagnostics developers to systematically evaluate their diagnostics on a collection of high-quality genotypes (genomic data) and phenotypes (antimicrobial resistance data) and identify their strengths and weaknesses. Third, the network identifies new policy directions that can support diagnostics development and adoption by accounting for the public health benefits of using AMR diagnostics. These developments will help AMR diagnostics cross the "valley of death" and help patients.Expected outcomes:An open, curated online AMR diagnostics developer directory (ADDD), building on AMR Insights' Technology Pages.A workshop to develop the standards for genotypes, phenotypes, and metadata, as well as the accompanying bacterial isolates for the VBP, building on previous achievements of the Seq4AMR network (Raphenya et al, 2022)A systematic approach for the management, selection and curation of gold standard NGS data, phenotype data, and metadata, as well as the corresponding bacterial isolates for the VBP.Communication, dissemination and roadmap open-access publication describing the VBP contents, its format, and the benchmark set selection protocol. Possible journals: Microbial Genomics or similar.A workshop to develop a proposal for a regulatory pathway to allow AMR diagnostics developers to benefit from incentives based on the public health benefits of their products.An open-access roadmap publication describing the proposed policy.

该网络 B2B2B AMRDx 汇集了来自大学（实验室）、医院（临床）、营利性组织（企业）、政府和非营利组织（其他）的不同研究人员群体，以应对其中一些挑战。我们拥有人类、动物和环境 AMR 方面的专业知识，来自 20 个不同的国家。该网络的目标如下。首先，该网络创建一个全面的在线 AMR 诊断开发人员目录 (ADDD)，以促进该领域的思想交流。其次，该网络扩展了 JPIAMR Seq4AMR 虚拟基准平台 (VBP)，使诊断开发人员能够系统地评估他们对高质量基因型（基因组数据）和表型（抗菌素耐药性数据）集合的诊断，并确定其优势和劣势。第三，该网络通过考虑使用 AMR 诊断的公共健康益处，确定了可以支持诊断开发和采用的新政策方向。这些进展将帮助 AMR 诊断跨越“死亡之谷”并帮助患者。预期成果：建立在 AMR Insights 技术页面基础上的开放式、精心策划的在线 AMR 诊断开发人员目录 (ADDD)。举办研讨会，制定基因型标准、表型、元数据以及 VBP 的随附细菌分离株，建立在 Seq4AMR 网络先前成就的基础上（Raphenya 等人，2022）一种系统方法用于管理、选择和整理金标准 NGS 数据、表型数据和元数据，以及 VBP 的相应细菌分离株。描述 VBP 内容、格式和基准的通信、传播和路线图开放获取出版物设置选择协议。可能的期刊：微生物基因组学或类似期刊。一个研讨会，旨在制定监管途径提案，使 AMR 诊断开发人员能够从基于其产品的公共健康益处的激励措施中受益。描述拟议政策的开放获取路线图出版物。

项目成果

Ten simple rules for the sharing of bacterial genotype-Phenotype data on antimicrobial resistance

共享抗菌素耐药性细菌基因型-表型数据的十个简单规则

• DOI: http://dx.10.1371/journal.pcbi.1011129
• 发表时间: 2023
• 期刊: PLOS Computational Biology
• 作者: Chindelevitch L