MRC TS Award: Dynamic Neuromodulation

MRC TS 奖：动态神经调节

• 批准号: MR/X023141/1
• 负责人: Hayriye Cagnan
• 金额: $ 52.36万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX023141%2F1
• 关键词: MRC; TS; Award; Dynamic; Neuromodulation

Brief neural rhythms, coordinated across multiple brain regions, control our everyday actions from reaching for a glass of water to making decisions. Dysfunction of this fundamental neural property has been linked to common conditions such as Parkinson's disease, Essential Tremor, and Dystonia, which impact more than one million people across the UK. Understanding the role of neural coordination in health and disease is key for the development of effective therapies.My research programme uses brain stimulation to establish the role of neural coordination in Parkinson's disease and Essential Tremor. During my Career Development Award, I worked towards:Theme 1: Establishing how the current state of a disease circuit influences the most effective stimulation strategy.Theme 2: Determining how selectively modulating neural coordination impacts goal-directed behaviour.Theme 3: Establishing the mechanisms through which our brains naturally control neural coordination.Theme 4: Determining whether it is possible to regulate neural coordination with brain stimulation by mimicking mechanisms through which our brains naturally control coordination.We have made good progress with Themes 1-3 and (a) implemented experimental tasks to better understand the link between symptom severity and movement, (b) built realistic computational models that capture the mechanisms underlying Essential Tremor and Parkinson's disease and (c) developed invasive and non-invasive stimulation strategies to reduce tremor and influence goal-directed behaviour. Due to several mitigating circumstances, we are still at the beginning stages of Theme 4 and require additional time. The Transition Support Award will be used to support this important body of work and consolidate my intermediate fellowship by supporting a key member of my team and protecting my research time.

跨多个大脑区域协调的短暂神经节律控制着我们的日常行为，从伸手拿一杯水到做出决定。这种基本神经特性的功能障碍与帕金森病、特发性震颤和肌张力障碍等常见疾病有关，这些疾病影响着英国超过一百万人。了解神经协调在健康和疾病中的作用是开发有效疗法的关键。我的研究项目使用大脑刺激来确定神经协调在帕金森病和特发性震颤中的作用。在获得职业发展奖期间，我致力于：主题 1：确定疾病回路的当前状态如何影响最有效的刺激策略。主题 2：确定选择性调节神经协调如何影响目标导向行为。主题 3：建立机制通过我们的大脑自然地控制神经协调。主题 4：确定是否可以通过模仿我们的大脑自然地控制协调的机制来通过大脑刺激来调节神经协调。我们在主题 1-​​3 和(a) 实施实验任务，以更好地了解症状严重程度和运动之间的联系，(b) 建立真实的计算模型，捕捉特发性震颤和帕金森病的潜在机制，(c) 开发侵入性和非侵入性刺激策略，以减少震颤和影响目标导向的行为。由于一些缓解情况，我们仍处于主题 4 的开始阶段，需要额外的时间。过渡支持奖将用于支持这项重要的工作，并通过支持我的团队的关键成员和保护我的研究时间来巩固我的中间奖学金。