BIODEMOGRAPHIC MODELS OF REPRODUCTIVE AGING

生殖衰老的生物人口学模型

• 批准号: 6169047
• 负责人: JAMES W WOOD
• 金额: $ 39.48万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6169047
• 关键词: aging; clinical research; estrogens; female; female reproductive system; follicle stimulating hormone; hormone regulation /control mechanism; human subject; longitudinal human study; luteinizing hormone; mathematical model; menopause; menstrual cycle; model design /development; progesterone; women's health; aging; clinical research; estrogens; female; female reproductive system; follicle stimulating hormone; hormone regulation /control mechanism; human subject; longitudinal human study; luteinizing hormone; mathematical model; menopause; menstrual cycle; model design /development; progesterone; women's health

DESCRIPTION: The research outlined in this application is designed to (1) characterize the transition to menopause in a well-defined cohort of U.S. women, (2) analyze patterns of individual-level variation in reproductive aging, (3) relate these patterns of variation to previous history including information on reproduction, menstrual patterns, and health, and (4) link the hormonal changes of menopause to the underlying etiologic process of follicular depletion. The study population includes women enrolled in the Tremin Trust project: these women have been providing detailed prospective reports of menstrual and reproductive histories and other information for up to 30 years. For around 150 of these women, urine specimens will be collected during a six-month window for up to five years.

描述：本应用程序中概述的研究旨在（1） 特征是在美国的一个定义明确的队列中过渡到更年期的过渡 妇女，（2）分析生殖级别变化的模式 衰老，（3）将这些变化模式与以前的历史相关联 有关生殖，月经模式和健康的信息，以及（4）链接 更年期对基本病因的激素变化 卵泡耗竭。 研究人群包括入学的妇女 Tremin Trust项目：这些妇女一直在提供详细的预期 月经和生殖历史以及其他信息的报告 到30年。 对于其中约150名女性，尿液标本将是 在六个月的窗口中收集了五年。