EPIDEMIOLOGIC STUDY OF THE LATE REPRODUCTIVE YEARS

生育后期的流行病学研究

• 批准号: 6149917
• 负责人: ELLEN W FREEMAN
• 金额: $ 58.07万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-10 至 2001-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6149917
• 关键词: African American; aging; behavioral /social science research tag; bioperiodicity; caucasian American; clinical research; dehydroepiandrosterone; developmental psychology; epidemiology; estradiol; female; follicle stimulating hormone; human middle age (35-64); human subject; longitudinal human study; luteinizing hormone; menopause; ovary; racial /ethnic difference; young adult human (21-34)

DESCRIPTION: (Adapted from the Investigators Abstract) This is a longitudinal study of hormones and symptoms of African-American and Caucasian women in their late reproductive years, ages 35-47. The specific aims are to: 1) characterize the fluctuations and rates of change of selected hormones: dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol; 2) evaluate psychological and physical symptoms commonly associated with reproductive aging; 3) correlate hormone changes with the severity of symptoms; 4) compare the result between African American and Caucasian women. The broad hypotheses are that: a) psychological and physical symptoms which occur with reproductive aging are associated with the fluctuations or rates of hormonal changes; b) DHEAS, an adrenal hormone marker of aging, may have a direct effect on psychological symptoms; c) psychological symptoms are not correlated with and occur prior to vasomotor symptoms and d) any difference in symptom and hormones compared between African American and Caucasian women is negligible after controlling for variables that have been found to differentiate these groups such as education, income, marital status, and body mass. A population-based sample of 400 women (200 African-American, 200 Caucasian) will be identified through random digit dialing. The women will be ages 35-47, with regular menstrual cycles at study enrollment. There will be six assessments, conducted at 9-month intervals, to evaluate the study variables over time. More than 80% of U.S. women experience psychological or physical symptoms in the waning reproductive years, with varying degrees of severity and disruption of normal functioning. This study will fill an important gap in the knowledge of relationships between hormone changes and symptoms in the late reproductive years and provide the first information on these factors in African-American women. In addition, the findings will be important for clinicians addressing fertility problems of women in their late reproductive years and will increase our understanding of the role of reproductive aging in the increased morbidity and mortality of postmenopausal women.

描述：（改编自调查员摘要）这是一个 非裔美国人和非裔美国人的激素和症状的纵向研究 处于生育后期（35-47 岁）的白人女性。 这 具体目标是：1）描述波动和速率的特征 所选激素的变化：硫酸脱氢表雄酮（DHEAS）， 卵泡刺激素 (FSH)、黄体生成素 (LH) 和 雌二醇； 2）共同评估心理和身体症状 与生殖衰老有关； 3）将激素变化与 症状的严重程度； 4）比较非裔美国人和非裔美国人之间的结果 白人女性。 广泛的假设是： a) 心理和 生殖衰老引起的身体症状与 荷尔蒙变化的波动或速度； b) DHEAS，一种肾上腺 衰老的激素标志物，可能对心理产生直接影响 症状; c) 心理症状与发生无关且不发生 在出现血管舒缩症状之前以及 d) 症状和激素有任何差异 非洲裔美国女性和白人女性之间的比较可以忽略不计 控制已发现的可以区分这些的变量 群体，如教育、收入、婚姻状况和体重。 基于人口的 400 名女性样本（200 名非洲裔美国人，200 名女性） 白种人）将通过随机数字拨号进行识别。 妇女们 研究入组时年龄为 35-47 岁，月经周期正常。 将进行六次评估，每 9 个月进行一次，以 随着时间的推移评估研究变量。 超过 80% 的美国女性经历过心理或身体症状 在生育年龄逐渐减弱的情况下，有不同程度的严重程度和 破坏正常功能。 这项研究将填补一个重要空白 了解激素变化和症状之间的关系 在生育后期并提供有关这些的第一个信息 非裔美国女性的因素。 此外，调查结果将 对于临床医生解决女性生育问题非常重要 晚育年龄并将增加我们对其作用的理解 生殖衰老导致发病率和死亡率增加 绝经后妇女。