MECHANISM-BASED MEASURES OF OTOLOGIC PATHOLOGY

基于机制的耳科病理学测量

• 批准号: 6043407
• 负责人: MANUEL DON
• 金额: $ 23.19万
• 依托单位: HOUSE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6043407
• 关键词: Meniere's disease; acoustic nerve; audiometry; clinical research; diagnosis design /evaluation; ear disorder diagnosis; human subject; nervous system neoplasms; neural transmission; noninvasive diagnosis

DESCRIPTION: (Adapted from the Investigator's Abstract) The project's long-term goal is to understand the effects of otologic pathology on mechanisms underlying human cochlear and brainstem processes. It proposes a mechanism-based approach that will provide (1) critical neuro-patho-physiological information, and (2) a scientific framework for early diagnoses of difficult-to-identify otologic diseases. In this approach, it uses newly-developed non-invasive measures of the auditory brainstem response (ABR) to investigate known and hypothesized pathological changes in the mechanisms underlying specific processes in the peripheral auditory system caused by small acoustic tumors and Meniere's disease. The specific aims are (1) to demonstrate that small (<1 cm) acoustic tumors alter the synchrony and/or amount of neural output to an extent greater than that predicted by audiometric thresholds, and (2) to determine if patients diagnosed with Meniere's disease have abnormal cochlear temporal-related measures consistent with the presence of cochlear hydrops. In addition, a comparative analysis of the results of these studies will determine whether the proposed measures can distinguish between small acoustic tumors and early Meniere's disease. The significance of the proposed work is that it will (1) provide new insight into the effects of otologic pathology on the theoretical and basic scientific mechanisms underlying the human peripheral auditory system, (2) demonstrate that non-invasive physiologic measures guided by a mechanism-based approach can lead to sensitive diagnoses for small acoustic tumors and early Meniere's disease with good specificity, (3) fill the need for non-invasive measures of peripheral auditory system functionality in humans as new therapeutic measures to improve, prevent destruction of, or possibly restore cochlear function are developed, and (4) test the predictive power of currently emerging models of cochlear and brainstem function across the domains of cochlear physiology, neurophysiology, electrophysiology, and pathology.

描述：（根据调查员的摘要改编）项目的长期 目标是了解耳科病理对机制的影响 人工耳蜗和脑干过程的基础。它提出了一个 基于机制的方法将提供（1）关键 Neuro-Patho生理信息，以及（2）早期的科学框架 难以识别的耳科疾病的诊断。在这种方法中，它使用 听觉脑干反应的新发达的非侵入性测量（ABR） 研究机制已知和假设的病理变化 外围听觉系统中的基本特定过程由小 声学肿瘤和Meniere病。 具体目的是（1）证明很小（<1 cm）的声学肿瘤 更改同步和/或神经输出量的程度大于 通过听众阈值预测的，（2）确定患者是否 被诊断为Meniere病具有异常的人工耳蜗有关 与人工耳蜗的存在一致的措施。另外， 这些研究结果的比较分析将决定 提议的措施可以区分小声学肿瘤和早期 Meniere病。 拟议工作的重要性是（1）提供新的见解 进入耳科病理对理论和基础科学的影响 人类外围听觉系统的基础机制，（2）证明 以基于机制的方法指导的非侵入性生理指标可以 导致对小声学肿瘤和早期Meniere的敏感诊断 特异性良好的疾病，（3）满足了对非侵入性测量的需求 作为新的治疗措施，人类的外围听觉系统功能 为了改进，防止破坏或可能还原人工耳蜗功能是 开发，（4）测试当前新兴模型的预测能力 人工耳蜗生理领域的人工耳蜗和脑干功能， 神经生理学，电生理学和病理学。