ADVANCES IN HUMAN BREAST AND PROSTATE CANCER

人类乳腺癌和前列腺癌的进展

• 批准号: 6083956
• 负责人: DENNIS J SLAMON
• 金额: $ 0.9万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-10 至 2001-03-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6083956
• 关键词: breast neoplasm /cancer diagnosis; breast neoplasms; cancer prevention; female; male; meeting /conference /symposium; neoplasm /cancer therapy; prostate neoplasms; travel

Human breast and prostate cancer continue to be major health problems today. Few significant inroads have been made on the death rates from these diseases using current diagnostic and therapeutic strategies. With the explosion of new information generated from research on the molecular, biochemical and cellular aspects of growth regulation in eukaryotic cells, significant insights have now been developed into the pathogenesis of these two malignancies. Genetic alterations involving critical growth factors, growth factor receptors, signal transduction pathways, transcription factors, cell cycle regulatory genes and tumor suppressor genes have been now shown to play important roles in various aspects of the malignant process in these diseases. In addition, knowledge regarding the role of non-malignant tissues such as vascular endothelial and immune cells play in the body's response to cancer have opened new avenues for cancer therapeutics directed at cells other than those that are malignant. This Keystone Symposium will be designed to integrate recent knowledge on the basic biology of human breast and prostate cancer with the development and testing of new experimental therapeutics. A laboratory to bedside theme will be developed and carried through the entire meeting with presentation and discussion of the most current basic research on the control of cell growth interfaced with results from testing new molecular therapeutic strategies based on this information. The topics of discussion will include strategies involving direct inhibition of molecules in growth regulatory pathways, introduction of normal genes through gene therapy to replace deleted or altered loci critical to growth regulation, approaches designed to generate host immune responses to tumor specific molecules through new vaccine development, trials directed at inhibition of angiogenesis in malignant tissues and prevention approaches based on recent knowledge regarding steroid hormone/receptor action and retinoid receptors in cell differentiation. We will highlight the exciting and very real area of active translational research, moving basic science information into new therapeutic approaches against breast and prostate cancer.

当今人类乳腺癌和前列腺癌仍然是主要的健康问题。 使用当前的诊断和治疗策略，这些疾病的死亡率几乎没有大量侵犯。 随着对真核细胞生长调节的分子，生化和细胞细胞方面的研究产生的新信息的爆炸，现在已经发展为这两种恶性肿瘤的发病机理。 现已证明，涉及关键生长因子，生长因子受体，信号转导途径，转录因子，细胞周期调节基因和肿瘤抑制基因的遗传改变在这些疾病中恶性过程的各个方面都起着重要作用。 此外，关于血管内皮和免疫细胞等非恶性组织在人体对癌症的反应中起作用的知识为针对细胞以外的细胞的癌症治疗途径开辟了新的途径。 该Keystone研讨会将旨在将有关人乳腺癌和前列腺癌基本生物学的最新知识与新实验疗法的开发和测试相结合。 在整个会议上，将开发和携带一个实验室，并讨论有关控制细胞生长的最新基础研究，并根据这些信息测试了新的分子治疗策略的结果。讨论的主题将包括涉及直接抑制分子在生长调节途径中的策略，通过基因治疗引入正常基因，以替代对生长调节至关重要的已缺失或改变的基因座，旨在通过新的疫苗发育对肿瘤特异性分子的宿主反应进行抑制，该方法基于对肿瘤的特定疫苗的影响，并针对抑制不抑制的动作群体，对肿瘤特异性分子进行了抑制，该试验对抑制态度的动作构成/抑制了动物的疾病，该试验是在抑制虫生成的动作。和细胞分化中的类视黄素受体。 我们将重点介绍主动转化研究的令人兴奋且非常真实的领域，将基础科学信息转化为针对乳腺癌和前列腺癌的新治疗方法。