ROLE OF NEURAL PLASTICITY IN CHEMICAL INTOLERANCE

神经可塑性在化学不耐受中的作用

• 批准号: 6095303
• 负责人: Barbara A Sorg
• 金额: $ 1.2万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6095303
• 关键词: chemical hypersensitivity; meeting /conference /symposium; neural plasticity

The New York Academy of Sciences is sponsoring a conference entitled: Role of Neural Plasticity in Chemical Intolerance in June 2000. The principal investigator and chair is Barbara Sorg, Ph.D., Washington State University. The co-chair is Iris Bell, M.D., Ph.D., Tucson Veterans Affairs Medical Center. Chemical intolerance (CI), also referred to as multiple chemical sensitivity, is a condition whereby individuals become increasingly sensitive to chemicals in the home and workplace. It is an emerging problem in environmental health. A wide variety of symptoms and severe illness from low-level chemical exposures have been reported in as high as 4-6% of the American population. Individuals with sensitivities to chemicals make an average of 23 health care provider visits per year. Thus, the economic impact of the CI condition and lack of treatment is potentially enormous. The main objective of the meeting is to gather neuroscientists from a variety of subdisciplines to discuss the potential mechanisms for the amplification of symptoms in individuals with CI. The meeting will provide a forum for the exchange of ideas in these subdisciplines in an effort to develop a series of testable hypotheses based upon the postulate that neural plasticity plays a role in the development of CI. While the primary focus of the meeting is on pre-clinical data, the program will also include scientists who will provide up-to-date information on the clinical aspects of CI. It is expected that these presentations by clinical and basic scientists will familiarize the audience with not only the primary clinical findings of CI but also basic biological findings related to neural plasticity as a potential critical link for mechanisms leading to CI in humans. The basic science findings will focus primarily on the cellular changes that mediate plasticity as well as alterations in brain pathways that regulate behavior. The findings will be integrated into a rationale for future basic research and clinical applications. Ultimately, the goal is to provide a greater understanding of the mechanism(s) of CI so that treatment strategies may be developed. The proceedings will be published as a volume in the Annals of the New York Academy of Sciences and will be distributed internationally.

纽约科学院赞助了一次题为：神经可塑性在2000年6月化学不耐受中的作用。该联合主席是图森退伍军人事务医学中心医学博士Iris Bell，博士。化学不耐受（CI）也称为多种化学敏感性，是个人对家庭和工作场所中化学物质越来越敏感的条件。这是环境健康中的一个新兴问题。据报道，低水平化学暴露的多种症状和严重疾病的高达4-6％的美国人口。对化学物质敏感的个人平均每年进行23家医疗保健提供者访问。因此，CI条件和缺乏治疗的经济影响可能是巨大的。会议的主要目的是从各种子学科中收集神经科学家，以讨论CI个体症状扩增的潜在机制。该会议将为这些子学科中的思想交换提供一个论坛，以基于假设神经可塑性在CI的发展中起作用的假设，以开发一系列可检验的假设。虽然会议的主要重点是临床前数据，但该计划还将包括科学家，他们将提供有关CI临床方面的最新信息。预计临床和基础科学家的这些演讲将不仅熟悉CI的主要临床发现，而且还将与神经可塑性有关的基本生物学发现，这是导致人类CI的机制的潜在关键联系。基础科学发现将主要集中在介导可塑性的细胞变化上，以及调节行为的大脑通路的改变。这些发现将纳入未来的基础研究和临床应用的基本原理中。最终，目标是对CI的机制有更深入的了解，以便可以制定治疗策略。会议记录将作为纽约科学院纪事的卷发表，并将在国际上分发。