LIPID MODIFICATIONS OF PROTEINS

蛋白质的脂质修饰

• 批准号: 6189717
• 负责人: DEBORAH Ann BROWN
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-07 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6189717
• 关键词: acylation; glycosylphosphatidylinositols; isoprenoid; lipid metabolism; meeting /conference /symposium; protein metabolism; travel

We request partial support for a Federation of American Societies of Experimental Biology (FASEB) conference "Lipid Modifications of Proteins", August 6-11, 2000 at Copper Mountain, CO, on structure and function of the three major classes of lipid modification; acylation, GPI-anchorage, and prenylation. This meeting relates to cancer because many lipid modified proteins (such as Ras and Src) are signaling proteins frequently mutated in human cancer. Lipid modification of these proteins is required for their transforming potential. Drugs that inhibit farnesylation of Ras can cause tumor regression in animal models and are in clinical trials. Bob Bishop of Schering Plough will speak on this topic. Membrane rafts (caveolae) are signaling centers that are important in both cancer and immunology. John Hancock will speak on how rafts affect signaling though H-Ras. Several reports show that T cell signaling occurs in rafts, as will be discussed by Marilyn Resh and Tony Magee. Another important focus of the meeting is on infectious disease. Lipid modification in pathogens such as Trypanosoma, Leishmania, and Plasmodium is crucial for pathogen survival, but has features not shared by mammalian hosts, and is an attractive target for pharmacological intervention. This avenue is being actively explored by Michael Ferguson (developing strategies for inhibiting GPI-anchorage in Trypanosoma brucei), by Jeffrey Gordon (looking at myristoylation in Candida albicans), by Fred Buckner (prenylation in Trypanosoma), and by Malcolm McConville (GPI-anchorage in Leishmania). In another strategy, Gisou van der Goot will discuss inhibition of intoxication by Aeromonas hydrophila toxin, which binds GPI-anchored proteins. The goal of this meeting can be summed up in the stated mission of NIGMS: it is "aimed at improving the molecular-level understanding of fundamental biological processes and discovering approaches to their control." Most participants will come from academics, with others from industry and research institutes. The conference has previously been very successful in attracting women, junior, minority, and international investigators. In addition to the themes outlined above, the following topics will be covered: Biosynthesis, trafficking and function of GPI anchored proteins; Enzymology of lipid modifications; Role of cholesterol in signaling and membrane domains; Biology of CAAX processing; and Lipid modifications and protein targeting.

我们要求对美国实验生物学联合会（FASEB）会议“蛋白质脂质修饰”的联合会部分支持，2000年8月6日至11日在Co，CO，CO，关于三种主要类脂质修饰的结构和功能；酰化，gpi裂缝和原始化。这次会议与癌症有关，因为许多脂质改性蛋白（例如RAS和SRC）是在人类癌症中经常突变的信号蛋白。 这些蛋白质的转化潜力需要对这些蛋白质的脂质修饰。 抑制RA的法尼化的药物可能在动物模型中引起肿瘤消退，并且正在临床试验中。 Schering Plow的鲍勃·毕晓普（Bob Bishop）将在这个话题上发表讲话。膜木筏（小窝）是在癌症和免疫学中都很重要的信号传导中心。 约翰·汉考克（John Hancock）将谈论筏子如何影响H-Ras的信号。 几份报告表明，T细胞信号传导发生在筏中，正如Marilyn Resh和Tony Magee所讨论的那样。会议的另一个重要重点是传染病。病原体（例如锥虫，利什曼原虫和疟原虫）等病原体中的脂质修饰对于病原体生存至关重要，但具有哺乳动物宿主没有共同的特征，并且是药理学干预的有吸引力的靶标。 迈克尔·弗格森（Michael Ferguson）（制定了抑制Brucei的Gpi-pantorage的策略），杰弗里·戈登（Jeffrey Gordon）（在白色念珠菌中查看Myristoylation），弗雷德·巴克纳（Fred Buckner）（Malcolm McConville（Malcolm McConville）（Gpi-andere）（Gpi-anderagore）（Gpi-Canneoragor），杰弗里·戈登（Jeffrey Gordon）（查看Myristoylation in Candida of Candida the candida），正在积极探索这一途径。在另一种策略中，Gisou van der Goot将讨论与GPI锚定蛋白结合的Hyrophila毒素对中毒的抑制。这次会议的目标可以在诺格姆斯的既定任务中概括：它“旨在提高对基本生物过程的分子级别的理解，并发现其控制方法”。大多数参与者将来自学者，其他参与者来自行业和研究机构。 该会议以前在吸引妇女，初中，少数群体和国际调查人员方面非常成功。 除了上述主题外，还将涵盖以下主题：GPI锚定蛋白的生物合成，运输和功能；脂质修饰的酶学；胆固醇在信号传导和膜结构域中的作用； Caax加工的生物学；以及脂质修饰和蛋白质靶向。