ENERGY EXPENDITURE AND THE INCIDENCE OF OBESITY

能量消耗和肥胖发生率

• 批准号: 6177476
• 负责人: LINDA G BANDINI
• 金额: $ 23.7万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6177476
• 关键词: adipose tissue; adolescence (12-20); basal metabolism; bioenergetics; body composition; body physical activity; body water; clinical research; diet; disease /disorder proneness /risk; epidemiology; family genetics; female; hormone regulation /control mechanism; human puberty; human subject; leptin; longitudinal human study; nutrition related tag; obesity; oxygen consumption; parents; racial /ethnic difference; smoking

Adolescence in girls is a critical period for the development of obesity. Reduced energy expenditure represents a strong risk factor. We are continuing to follow annually a cohort (originally 197 pre- menarcheal girls) who were enrolled (1990-1993) in a longitudinal study of energy expenditure and its relationship to the development of obesity. One hundred and fifty-nine girls (80.7%) remain active in the study. Of these 159 subjects, 59 have completed the study and the other 100 continue to seen annually. A baseline measures of body composition, resting metabolic rate, total daily energy expenditure, and VO2 max were completed. Measures of diet and activity were obtained from a 7-day food record, a 7-day activity record, and activity questionnaires. Since enrollment, girls are seen annually until 4 years after menarche when they exit the study. At their annual visit, measures of diet, activity, growth and body composition by anthropometric measures are obtained. Blood is drawn for the measurement of sex hormones and insulin. At the end of this proposed grant period, all but five girls will be 4 years post menarcheal and will exit the study. At that time we will have determined whether reductions in energy expenditure at baseline (total daily energy expenditures, resting energy expenditure, percent non- resting energy expenditure or VO2 max) are associated with increases in body fat as girls mature. We will also determine whether differences in ethnicity, or parental obesity contribute to the changes in body fat in a subcohort of girls, visceral fat was previously measured at menarche by MRI. At the time of the MRI, measures of body composition and anthropometry were repeated, blood was drawn for the measurement of sex hormones, and questionnaires were completed rating to diet, activity and behaviors such as smoking and alcohol abuse. We will repeat these measures in these girls at their exit visit. This study will allow us to determine what factors contribute to visceral fat deposition in girls during puberty. These studies will clarify the role of energy expenditure in the development of obesity and identify factors that contribute to the deposition of visceral fat. Identification of factors which contribute to the development of obesity and central fat distribution will aid in the development of programs designed to reduce the incidence and morbidity associated with adolescent obesity.

女孩的青春期是肥胖发展的关键时期。减少的能源消耗代表了强大的危险因素。我们将继续每年遵循一名队列（最初是197个初级前女孩），他们参加了（1990- 1993年）的纵向研究及其与肥胖发展的关系。一百五十九个女孩（80.7％）在研究中保持活跃。在这159名受试者中，有59名已经完成了这项研究，其他100名每年继续看到。完成了人体成分，静息代谢率，总每日能量消耗和MAX的基线测量。饮食和活动的度量是从7天的食物记录，7天的活动记录和活动问卷中获得的。自从入学人数以来，每年都会看到女孩退出研究后的4年。在年度访问中，通过人体测量措施对饮食，活动，生长和身体成分进行了衡量。抽血是为了测量性激素和胰岛素。在此拟议的赠款期结束时，除五个女孩外，所有几个女孩都将在初级后期4年，并将退出研究。当时，我们将确定基线时能量消耗的减少（每日能量消耗，静息能量消耗，非静息能量消耗百分比或最大值）是否与随着女孩成熟的身体脂肪的增加有关。我们还将确定种族差异或父母肥胖的差异是否有助于女生的体内脂肪的变化，MRI先前在初潮时测量了内脏脂肪。在MRI时，重复了人体成分和人体测量法的测量，抽血以测量性激素，并完成了问卷调查，将饮食，活动和行为（例如吸烟和酗酒）评为评级。在这些女孩退出访问时，我们将重复这些措施。这项研究将使我们能够确定哪些因素导致青春期女孩的内脏脂肪沉积。这些研究将阐明能量消耗在肥胖发展中的作用，并确定有助于内脏脂肪沉积的因素。鉴定有助于肥胖和中央脂肪分布发展的因素将有助于制定旨在减少与青少年肥胖相关的发病率和发病率的计划。