Pioneering Renovite nanoclay gels in cell therapy

细胞治疗领域开创性的 Renovite 纳米粘土凝胶

• 批准号: MR/W013002/1
• 负责人: Agnieszka Janeczek
• 金额: $ 102.04万
• 依托单位: Renovos Biologics Limited
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW013002%2F1
• 关键词: Pioneering; Renovite; nanoclay; gels; cell

Synthetic nanoclays can form hydrogels that act as tissue templates and can be used to encapsulate, deliver and crucially, retain various molecules at a required site to influence tissue regeneration. Critically, Renovos has been pioneering the use of this novel material, Renovite, for medical applications as an injectable gel for localised protein delivery. We have now established a new synthesis capability for Renovite nanoclay gels, extending the avenues for development for this industrially sustainable biomaterial across regenerative medicine. Due to the ability of the nanoclay gels to localise and retain molecules, this type of local delivery application offers improved safety and allows for lowering of the effective dose of many biologics that can be otherwise toxic.Nanoclay gels are also potentially excellent candidates for delivering cells as the nanoclays allow diffusion of nutrients and their basic physical properties mimic the cell's native environment. I will pioneer the use of this novel, synthetic gel biomaterial for application in cell therapy, building on the regenerative protein delivery background within Renovos and my expertise and interests in stem cell research. The largest unmet need from a medical and commercial perspective is novel biomaterial solutions that improve delivery and localisation for cells used in clinical practice (chondrocytes / autologous chondrocyte implantation or ACI) for cartilage regeneration or bone marrow aspirates (BMAs) for regenerative and immune modulating applications in cartilage and bone. This fellowship will provide innovation in cell therapy by delivering cutting-edge solutions based on a cost-effective, disruptive and highly competitive nanoclay biomaterial.

合成纳米粘土可以形成水凝胶，充当组织模板，并可用于封装、输送，最重要的是，将各种分子保留在所需部位以影响组织再生。重要的是，Renovos 一直率先将这种新型材料 Renovite 用于医疗应用，作为局部蛋白质输送的可注射凝胶。我们现已建立了 Renovite 纳米粘土凝胶的新合成能力，扩展了这种工业可持续生物材料在再生医学领域的开发途径。由于纳米粘土凝胶能够定位和保留分子，这种类型的局部递送应用提供了更高的安全性，并允许降低许多可能有毒的生物制剂的有效剂量。纳米粘土凝胶也是递送细胞的潜在优秀候选者因为纳米粘土允许营养物质扩散，并且它们的基本物理特性模仿细胞的原生环境。基于 Renovos 的再生蛋白递送背景以及我在干细胞研究方面的专业知识和兴趣，我将率先将这种新型合成凝胶生物材料用于细胞治疗。从医疗和商业角度来看，最大的未满足需求是新型生物材料解决方案，可改善临床实践中用于软骨再生的细胞（软骨细胞/自体软骨细胞植入或 ACI）或用于再生和免疫调节应用的骨髓抽吸物（BMA）的输送和定位在软骨和骨骼中。该奖学金将通过提供基于具有成本效益、颠覆性和高度竞争力的纳米粘土生物材料的尖端解决方案，为细胞治疗提供创新。