METHAMPHETAMINE DEPENDENCE AND THE RISK OF HIV INFECTION

甲基苯丙胺依赖和艾滋病毒感染风险

• 批准号: 6175496
• 负责人: GANTT P GALLOWAY
• 金额: $ 45.97万
• 依托单位: HEALTHRIGHT 360
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6175496
• 关键词: HIV infections; behavior prediction; behavioral /social science research tag; clinical research; comorbidity; drug addiction; hepatitis B; hepatitis C; high risk behavior /lifestyle; human T cell leukemia; human subject; methamphetamine; psychological tests; sex behavior; substance abuse epidemiology; substance abuse related behavior

DESCRIPTION: (Applicant's Abstract) Methamphetamine (MA) dependence is expanding rapidly in the United States, recapitulating early phases of epidemic spread in the 1950's and 1960's. Beyond the morbidity and mortality directly associated with addictive disease, MA is of particular concern in light of the HIV epidemic because it is often administered intravenously and it often increases libido. This confluence of sexual and injection drug use (IDU) risk factors has led to high HIV seroprevalence in MA using populations. Despite the rapid increase in MA dependence, little is known of its natural history and the relative contributions of sexual and IDU behaviors to the risk of HIV transmission. In a longitudinal study of MA dependence, we will use a comprehensive battery of assessments to identify predictors of high risk behaviors; the relative contributions of various sexual and IDU factors to HIV seropositivity; rates of HIV seroconversion; changes in risk behaviors and MA use following drug treatment; and the prevalence and stability of psychiatric comorbidity. Subjects will be recruited from the largely homosexual outpatient population at Haight Ashbury Detox in San Francisco, from predominately heterosexual outpatient population at The Effort in Sacramento, and from out-of-treatment MA users in San Francisco and Sacramento.

描述：（申请人的摘要） 甲基苯丙胺（MA）依赖性在美国正在迅速扩展 在1950年代和1960年代概括了流行病的早期阶段。 超越与成瘾性直接相关的发病率和死亡率 疾病，鉴于HIV的流行，MA特别关注 通常是静脉内给药的，并且通常会增加性欲。 这 性和注射药物使用（IDU）风险因素的汇合导致 使用种群在MA中的HIV血清阳性高。 尽管MA依赖性迅速增加，但知之甚少 历史以及性行为和IDU行为的相对贡献 艾滋病毒传播的风险。 在对MA依赖的纵向研究中，我们将 使用全面的评估来确定高的预测指标 风险行为；各种性和IDU因素的相对贡献 艾滋病毒血清阳性； HIV血清转化率；风险变化 药物治疗后的行为和MA使用；以及患病率和 精神病合并症的稳定性。 主题将从 SAN Haight Ashbury排毒的主要同性恋门诊 弗朗西斯科（Francisco），主要来自异性恋门诊 萨克拉曼多的努力以及旧金山的失败MA用户的努力 和萨克拉曼多。