A self-driven intramedullary nail for the reconstruction of large bone defects

用于重建大骨缺损的自驱动髓内钉

• 批准号: MR/Z503836/1
• 负责人: Anthony Bull
• 金额: $ 31.2万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FZ503836%2F1
• 关键词: self; driven; intramedullary; nail; reconstruction

This project aims to evaluate a self-driven bone transport nail developed to reconstruct large bone defects caused by trauma, deformity, or cancer. Bone transport is an intervention whereby new bone is grown in a long bone where there is a missing section. It requires the division of the intact portion of the bone leaving a segment of bone that can be transported from its location in a controlled manner using either an intramedullary nail or an external ring fixation. External fixation is the preferred technique in the UK due to lower cost and lack of availability of other options that has a number of significant limitations, which are: prolonged treatment time, diligent care, as well as psychological, hygiene, and daily activity burden for patients and caregivers. Intramedullary bone transport methods also have a number of limitations that include: the daily involvement of patients during the distraction process; regular interventions by surgeons; and the significant cost of the procedure. These limitations have led to limited use of this method regardless of its superior outcomes compared to the external fixator method.Addressing these limitations is the subject of this project: automating the process and significantly reducing its cost can considerably promote the use of nails in the UK as the primary technique for bone transport. In this project, we will experimentally demonstrate the feasibility and accuracy of the nail using an in vivo study on sheep. We will also engage with patient groups at the Royal National Orthopaedic Hospital during the study. This is to ensure it is well accepted and can be rapidly included in the current treatment pathway within the NHS once the clinical trials have been completed.

该项目旨在评估一种自驱动骨运输钉，用于重建由创伤、畸形或癌症引起的大骨缺损。骨运输是一种干预措施，使新骨在长骨缺失部分中生长。它需要分割骨头的完整部分，留下一段骨头，可以使用髓内钉或外环固定以受控的方式从其位置运输。外固定器是英国的首选技术，因为成本较低且缺乏其他选择，这些选择具有许多明显的局限性，包括：治疗时间长、护理繁琐，以及心理、卫生和日常活动负担。患者和护理人员。髓内骨转运方法也有许多局限性，包括：患者每天在牵引过程中参与；外科医生定期干预；以及该过程的巨大成本。这些限制导致该方法的使用受到限制，尽管与外固定器方法相比其效果更好。解决这些限制是该项目的主题：自动化流程并显着降低其成本可以大大促进钉子在英国的使用作为骨运输的主要技术。在这个项目中，我们将通过对绵羊的体内研究来实验证明指甲的可行性和准确性。在研究期间，我们还将与皇家国家骨科医院的患者团体进行接触。这是为了确保它得到广泛接受，并在临床试验完成后能够迅速纳入 NHS 内当前的治疗途径。