A self-driven intramedullary nail for the reconstruction of large bone defects

用于重建大骨缺损的自驱动髓内钉

• 批准号: MR/Z503836/1
• 负责人: Anthony Bull
• 金额: $ 31.2万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FZ503836%2F1
• 关键词: self; driven; intramedullary; nail; reconstruction

This project aims to evaluate a self-driven bone transport nail developed to reconstruct large bone defects caused by trauma, deformity, or cancer. Bone transport is an intervention whereby new bone is grown in a long bone where there is a missing section. It requires the division of the intact portion of the bone leaving a segment of bone that can be transported from its location in a controlled manner using either an intramedullary nail or an external ring fixation. External fixation is the preferred technique in the UK due to lower cost and lack of availability of other options that has a number of significant limitations, which are: prolonged treatment time, diligent care, as well as psychological, hygiene, and daily activity burden for patients and caregivers. Intramedullary bone transport methods also have a number of limitations that include: the daily involvement of patients during the distraction process; regular interventions by surgeons; and the significant cost of the procedure. These limitations have led to limited use of this method regardless of its superior outcomes compared to the external fixator method.Addressing these limitations is the subject of this project: automating the process and significantly reducing its cost can considerably promote the use of nails in the UK as the primary technique for bone transport. In this project, we will experimentally demonstrate the feasibility and accuracy of the nail using an in vivo study on sheep. We will also engage with patient groups at the Royal National Orthopaedic Hospital during the study. This is to ensure it is well accepted and can be rapidly included in the current treatment pathway within the NHS once the clinical trials have been completed.

该项目旨在评估开发出一种由创伤，畸形或癌症引起的大骨缺损的自动骨运输指甲。骨运输是一种干预措施，在其中，新的骨头在缺少部分的长骨中生长。它要求将骨骼完整部分划分，留下一部分骨骼，该骨骼可以使用内内指甲或外部环固定以受控方式从其位置运输。外部固定是英国首选技术，因为成本较低，并且缺乏其他具有许多限制的选择，即：延长治疗时间，勤奋的护理以及心理学，卫生和患者和护理人员的日常活动负担。髓内骨运输方法还具有许多局限性，其中包括：分心过程中患者的日常参与；外科医生定期干预；以及该程序的重​​大成本。与外部固定器方法相比，这些局限性导致了这种方法的使用限制。对这些限制进行补充是该项目的主题：自动化过程并大大降低其成本可以大大促进英国在英国用作骨运输的主要技术。在这个项目中，我们将使用对绵羊的体内研究在实验上证明指甲的可行性和准确性。在研究期间，我们还将与皇家国家骨科医院的患者团体互动。这是为了确保它已被公认，并且一旦完成临床试验，就可以迅速将其纳入NHS的当前治疗途径中。