NEW BIOMARKER OF BREAST CANCER IN BREATH

呼吸中乳腺癌的新生物标志物

• 批准号: 2868012
• 负责人: Michael Phillips
• 金额: $ 10万
• 依托单位: MENSSANA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2868012
• 关键词: alkanes; biomarker; breast neoplasms; breath tests; clinical research; diagnosis design /evaluation; female; human subject; neoplasm /cancer diagnosis; noninvasive diagnosis; oxidative stress

DESCRIPTION (adapted from the applicant's abstract): Oxidative stress in cancer cells generates oxygen free radicals which degrade cell membranes by lipid peroxidation. Polyunsaturated fatty acids are converted to alkanes that are excreted in the breath or degraded by cytochrome p450 enzymes. In a pilot study, an advanced new test for breath alkanes distinguished women with breast cancer from cancer-free controls. Hypothesis: The breath alkane test may provide a new biomarker of breast cancer. Experimental plan to test the hypothesis: Breath alkane tests will be performed in 170 women undergoing biopsy of a breast mass. The short-term aim of the research is to determine the sensitivity and specificity of the breath alkane test as a biomarker to breast cancer. Long-term aims of the research: If the breath alkane test is confirmed as a sensitive and specific biomarker of breast cancer, the instrumentation will be developed into a portable purpose-built apparatus. This device would be comparatively inexpensive and suitable for rapid mass screening of large populations of women for breast cancer. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：癌症中的氧化应激 细胞产生氧气自由基，从而通过脂质降解细胞膜 过氧化。多不饱和脂肪酸转化为烷烃 在呼吸中排出或被细胞色素P450酶降解。在飞行员中 研究，呼吸烷烃的高级新测试 无癌对照的癌症。假设：呼吸烷烃测试可能 提供新的乳腺癌生物标志物。测试的实验计划 假设：将在170名接受的女性中进行呼吸烷基测试 乳房的活检。该研究的短期目的是确定 呼吸烷烃测试的敏感性和特异性作为乳腺的生物标志物 癌症。研究的长期目标：如果确认呼吸烷基测试 作为乳腺癌的敏感和特定的生物标志物，仪器 将发展为便携式专用设备。这个设备将是 相对便宜，适合快速质量筛查大型 女性患乳腺癌的人群。 拟议的商业应用程序：不可用

项目成果

Volatile markers of breast cancer in the breath.

• DOI: 10.1046/j.1524-4741.2003.09309.x
• 发表时间: 2003-05-01
• 期刊: The breast journal
• 作者: Phillips, Michael;Cataneo, Renee N;Wong, Cynthia
• 通讯作者: Wong, Cynthia