ELECTROTHERAPY REVERSES INFRAMALLEOLAR ISCHEMIA

电疗可逆转踝下缺血

• 批准号: 2767992
• 负责人: ROBERT J GOLDMAN
• 金额: $ 14.37万
• 依托单位: CHATTANOOGA GROUP
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-05 至 2003-07-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2767992
• 关键词: biomedical equipment development; clinical research; coulometry; electronic stimulator; human subject; ischemia; oximetry; peripheral blood vessel; physical therapy; therapy; ulcer

DESCRIPTION: ( Adapted from the applicant's abstract). The applicants propose to use electrotherapy known as High Volt Pulsed Galvanic Stimulation (HVPGS) to stimulate improved blood flow to the peripheral vascular circulation for the treatment of peripheral vascular disease. HVPGS consists of direct, coupled continuous trains of pulses, each a submicrosecond doublet of high (>10 ma) peak amplitude. This signal augments microcirculation, as measured by transcutaneous oxygen (TcPO2), despite large vessel obstructive disease. For ischemic ulcers and incisions, HVPGS enhances the microcirculation transiently during treatment and slowly and persistently during the course of repeated treatments. HVPGS may produce arterial vasodilatation through a mechanism that is similar to the neuro inflammatory "wheel and flare" response. The investigators will conduct an unblinded, controlled clinical trial in a patient cohort with known chronicity and defined microvascular disease. Reperfusion of ischemic skin will be confirmed by TcPO2 oximetry and laser Doppler flow measurements. Microcirculaton improvements will be correlated with wound reduction and limb salvage rates. If outcomes are positive, electrotherapy should augment limb salvage and decrease amputation rates. PROPOSED COMMERCIAL APPLICATION: Wound care market Limb salavage market

描述：（根据申请人的摘要进行了改编）。申请人建议 使用称为高压脉冲电刺激（HVPG）的电疗疗法 刺激改善血液流向周围血管循环的血液 外周血管疾病的治疗。 HVPG由直接，耦合组成 连续的脉冲火车，每种脉冲均为高高（> 10 mA） 峰幅度。该信号增加了微循环，如 尽管较大的血管阻塞性疾病，但经皮氧（TCPO2）。为了 缺血性溃疡和切口，HVPG瞬时增强了微循环 在治疗期间，在重复过程中缓慢而持久 治疗。 HVPG可以通过一种机制产生动脉血管扩张 类似于神经炎症的“车轮和耀斑”反应。这 调查人员将在患者中进行一项无盲，受控的临床试验 伴有已知慢性和定义的微血管疾病的队列。再灌注 缺血性皮肤将通过TCPO2血氧仪和激光多普勒流动证实 测量。微电路的改进将与伤口相关 降低和肢体打捞率。如果结果是阳性的，则电疗应该 增强肢体打捞并降低截肢率。 拟议的商业应用： 伤口护理市场 肢体分子市场

项目成果

Electrotherapy reoxygenates inframalleolar ischemic wounds on diabetic patients: a case series.

• DOI: 10.1097/00129334-200205000-00006
• 发表时间: 2002-05-01
• 期刊: Advances in skin & wound care
• 影响因子: 2.4
• 作者: Goldman, Robert J;Brewley, Barbara I;Golden, Michael A
• 通讯作者: Golden, Michael A

Electrotherapy reverses inframalleolar ischemia: a retrospective, observational study.

• DOI: 10.1097/00129334-200303000-00009
• 发表时间: 2003-03-01
• 期刊: Advances in skin & wound care
• 影响因子: 2.4
• 作者: Goldman, Robert;Brewley, Barbara;Golden, Michael
• 通讯作者: Golden, Michael