ICF Biologically derived wraps for nerve and tendon regeneration

ICF 生物衍生包裹物，用于神经和肌腱再生

• 批准号: MR/Z503733/1
• 负责人: Lisa White
• 金额: $ 31.73万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FZ503733%2F1
• 关键词: ICF; Biologically; derived; wraps; nerve

Our team is working on an exciting new material that could revolutionise how we repair damaged nerves and tendons. This material, made from a special kind of natural gel, is stronger and more flexible than what's currently available. It's designed to support the body's own healing process, making it a promising tool in regenerative medicine. Initially, we focused on making this gel stronger by using a natural substance found in plants. This approach has proven successful, creating a material that's not only safe for the body but also versatile in its use. It can be shaped in different ways, like wraps for injured nerves or tendons, or even as tiny tubes for repairing small gaps in nerves. Our collaboration with TYBR Health, a company specialising in medical devices, has been crucial. Together, we've been refining our material to meet the specific needs of tendon repair. We've even developed a version that's easy to store and ready to use, which is a big step forward. We've already tested this material in lab settings and in animal models, and the results are promising. It seems to work well without causing any unwanted reactions in the body. Now, we're looking to take this research to the next level. We want to make sure it's effective and safe for use in real-world medical situations. In this project we will test the material in two small animal models and we'll examine how our material compares to materials already used clinically. This project has the potential to make a big difference in how we treat injuries to nerves and tendons, offering new hope for faster and more effective healing.

我们的团队正在研究一种令人兴奋的新材料，它可以彻底改变我们修复受损神经和肌腱的方式。这种材料由一种特殊的天然凝胶制成，比目前可用的材料更坚固、更柔韧。它的设计目的是支持人体自身的愈合过程，使其成为再生医学中很有前途的工具。最初，我们致力于通过使用植物中的天然物质来增强这种凝胶的强度。这种方法已被证明是成功的，创造了一种不仅对身体安全而且用途广泛的材料。它可以以不同的方式成型，例如包裹受伤的神经或肌腱，甚至作为修复神经小间隙的小管。我们与 TYBR Health（一家专门从事医疗设备的公司）的合作至关重要。我们一起不断改进我们的材料，以满足肌腱修复的特定需求。我们甚至开发了一个易于存储且易于使用的版本，这是向前迈出的一大步。我们已经在实验室环境和动物模型中测试了这种材料，结果令人鼓舞。它似乎效果很好，不会对身体造成任何不良反应。现在，我们希望将这项研究提升到一个新的水平。我们希望确保它在现实医疗情况下有效且安全地使用。在这个项目中，我们将在两个小动物模型中测试该材料，并检查我们的材料与临床上已使用的材料的比较。该项目有可能对我们治疗神经和肌腱损伤的方式产生重大影响，为更快、更有效的康复带来新的希望。