GENETICS OF HYPERTENSION IN BLACKS

黑人高血压的遗传学

• 批准号: 6356627
• 负责人: RIchard Stanley Cooper
• 金额: $ 6.73万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356627
• 关键词: African; African American; African Caribbean; blood pressure; body physical characteristic; cardiovascular disorder epidemiology; clinical chemistry; disease /disorder proneness /risk; environment associated hypertension; familial hypertension; family genetics; gene expression; genetic markers; genetic polymorphism; genotype; human genetic material tag; human population study; human subject; linkage mapping; peptidyl dipeptidase A; phenotype; renin angiotensin system; urinalysis

DESCRIPTION (Adapted from the Applicant's Abstract): This competitive renewal application requests support to continue a study of hypertension in populations of West African origin. During the first cycle 4,000 family members were recruited from Nigeria, Jamaica, and metropolitan Chicago, IL. Epidemiologic and genetic relationships have been demonstrated for angiotensin I-converting enzyme (ACE) and angiotensinogen (AGT). These genetically related populations live in highly contrasting social settings and a major focus of this project is how environment influences the expression of hypertension-related traits. Substantial differences in familial patterns have been identified in comparisons among the three population samples, suggesting gene-environment interactions. In this renewal phase the total sample will be increased to 6,000 family members. To further elucidate the environmental pathways we will conduct a sub-study cross-classifying participants on the major risk determinants (ie, obesity and sodium intake) and examine gene-environment interactions directly. A genome scan will be used in linkage analysis to identify new chromosomal regions of interest. Two new candidate loci (adducin and beta-2 adrenergic receptor) will be examined and association studies will be conducted using single nucleotide polymorphisms. The full range of analytic tools, including segregation, linkage and cladistic analysis, will be used.

描述（改编自申请人的摘要）：这种竞争性更新 申请请求支持继续研究人群中的高血压 西非来源。在第一个周期中，有4,000名家庭成员是 从尼日利亚，牙买加和伊利诺伊州芝加哥大都会招募。流行病学 血管紧张素I转换已经证明了遗传关系 酶（ACE）和血管紧张素原（AGT）。这些遗传相关的人群 生活在高度对比的社交环境中，该项目的重点是 环境如何影响高血压相关性状的表达。 在家族模式上存在实质性差异 三个人群样本的比较，表明基因环境 互动。 在此续签阶段，总样本将增加到6,000个家庭 成员。为了进一步阐明环境途径，我们将进行一次 主要风险决定因素的子研究跨分类参与者（即 肥胖和钠摄入量）并直接检查基因环境相互作用。 基因组扫描将用于链接分析以识别新的染色体 利益区域。两个新的候选基因座（Adducin和beta-2肾上腺素能 将检查受体），并将使用 单核苷酸多态性。包括 将使用隔离，链接和cladistic分析。