Molecular determinants of cardiolipin signalling in mitochondria

线粒体心磷脂信号传导的分子决定因素

• 批准号: MR/Y01975X/1
• 负责人: Sarah Rouse
• 金额: $ 75.66万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY01975X%2F1
• 关键词: Molecular; determinants; cardiolipin; signalling; mitochondria

My research focusses on mitochondria, important components of our cells. Mitochondria have two membranes, separating them from the rest of the cell; an inner, folded membrane and an outer membrane. The way these two membranes interact has critical roles in human health and disease, and dysregulation of these processes has been linked to neurodegenerative disorders, cardiomyopathy and neurological disease. My group are building 3D, dynamic models of mitochondria by using computational simulations alongside experimental approaches including cryo-electron tomography. This programme represents a comprehensive, multidisciplinary molecular level study of both membranes of the mitochondria and how they behave in concert and will give us new understanding of how we might control these pathways. The new understanding generated by my research programme will be applied to study other related pathways and, long-term, will be expected to lead to potential new drug targets in mitochondrial quality control pathways. Advancements in understanding membrane protein-lipid interactions in general will also have implications for the advancement of drug discovery programmes.

我的研究重点是线粒体，它是我们细胞的重要组成部分。线粒体有两层膜，将它们与细胞的其他部分分开。内折叠膜和外膜。这两种膜相互作用的方式在人类健康和疾病中起着至关重要的作用，这些过程的失调与神经退行性疾病、心肌病和神经系统疾病有关。我的团队正在通过使用计算模拟以及冷冻电子断层扫描等实验方法来构建线粒体的 3D 动态模型。该计划代表了对线粒体两膜及其协同行为的全面、多学科分子水平研究，并将让我们对如何控制这些途径有新的认识。我的研究计划产生的新认识将应用于研究其他相关途径，并且从长远来看，预计将在线粒体质量控制途径中产生潜在的新药物靶点。一般来说，理解膜蛋白-脂质相互作用的进展也将对药物发现计划的进步产生影响。