UCL Neurodegenerative Disease Human Tissue Resource

伦敦大学学院神经退行性疾病人体组织资源

• 批准号: MR/Y00440X/1
• 负责人: Thomas Warner
• 金额: $ 133.06万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY00440X%2F1
• 关键词: UCL; Neurodegenerative; Disease; Human; Tissue

Diseases of the brain and spinal cord are common and affect increasing numbers of people with advancing age. Conditions like Alzheimer's (AD) and Parkinson's (PD) affect a many elderly individuals, but can also present from young adult life particularly when there is a genetic cause. The same is true for other dementias and motor neuron disease (MND). These conditions are all characterised by death of specific groups of neurons (brain cells) and are referred to as neurodegenerative diseases (NDDs). They are progressive and eventually fatal and, currently, there is no cure for these disorders and a major source of disability in the population.Scientists and doctors are working to understand these and many other conditions, but the causes and methods for treating them require much more research. While valuable information can be obtained from animal models of disease, cells grown in a dish, and even computer simulations, there is no substitute for testing ideas in human tissue itself. Human tissue research is often a preliminary step before embarking on a clinical trial, especially for new treatments. For this reason, 'biobanks' have been developed that collect, characterize and store brain and spinal cord tissues from humans, both with and without nervous system diseases. These tissues, and associated data, are then provided to research projects thatneed to study human tissue.The goals of this proposal are several-fold. First, the current collection procedures will be greatly expanded by recruiting brain and nervous tissue donation from eight cohorts of very well studied patients with a variety of NDDs including AD and other dementias, PD, MND as well as control brains. A novel pilot study relates to Down Syndrome, a common cause of intellectual disability and early AD type dementia. We will collect brain material from embryos, fetuses, children and adults with this condition so we can understand the development of the condition in the brain over the entire lifespan. This lifespan approach can then be implemented for other NDDs particularly genetic ones. Secondly, we need to maximize the value of the donated brain material. This includes reducing the time-gap between death of the individual and acquisition of the brain, so that the tissue is as healthy as possible for research. Many types of data need to be linked to each brain sample, to provide a rich resource for the researchers, and this includes informationfrom hospital notes, imaging data like MRIs, lab results, and microscope slides from the pathology department. Genetic data (the DNA sequence) is particularly valuable for research, and we will ensure that all samples undergo genetic analysis.The third goal of this proposal is to develop a user-friendly web-based computer platform where all samples and associated clinical information are catalogued, so they can be searched by researchers who are seeking particular tissue types, diseases or stages. Working with the MRC Dementias Platform UK informatics team we will develop such a platform.The UCL Neurodegenerative disease Human nervous tissue resource will offer a step-change in the provision of tissue for research in this area.

大脑和脊髓的疾病很常见，并且会影响年龄增长的人数增加。阿尔茨海默氏症（AD）和帕金森氏症（PD）等条件会影响许多老年人，但也可以从成年人的生活中出现，尤其是在存在遗传原因的情况下。对于其他痴呆症和运动神经元疾病（MND）也是如此。这些疾病的特征是特定神经元（脑细胞）的死亡，被称为神经退行性疾病（NDDS）。它们是进步性的，最终是致命的，目前尚无治愈这些疾病的治疗方法，也是人群中的主要残疾来源。科学家和医生正在努力理解这些疾病和许多其他疾病，但是治疗它们的原因和方法需要更多的研究。虽然可以从疾病动物模型，在菜肴中生长的细胞甚至计算机模拟获得有价值的信息，但无法替代人类组织本身的想法。人体组织研究通常是进行临床试验之前的初步步骤，尤其是针对新治疗。因此，已经开发出“生物库”，这些“生物库”收集，表征和存储来自和没有神经系统疾病的人类的大脑和脊髓组织。然后将这些组织和相关的数据提供给研究人体组织的研究项目。该提案的目标是几倍。首先，通过从八个精心研究的患者中招募大脑和神经组织捐赠，包括AD和其他痴呆症，PD，MND以及控制大脑，将大大扩展当前的收集程序。一项新型的试点研究与唐氏综合症有关，唐氏综合症是智力障碍和早期AD型痴呆症的常见原因。我们将从具有这种状况的胚胎，胎儿，儿童和成人那里收集大脑材料，因此我们可以在整个生命周期内了解大脑中病情的发展。然后可以针对其他NDD尤其是遗传方法来实施这种寿命方法。其次，我们需要最大程度地提高捐赠的大脑材料的价值。这包括减少个体死亡与大脑获取之间的时间差距，以便组织尽可能健康。需要将许多类型的数据链接到每个大脑样本，以为研究人员提供丰富的资源，其中包括医院注释，成像数据，例如MRIS，LAB结果和病理学系的显微镜幻灯片。遗传数据（DNA序列）对于研究特别有价值，我们将确保所有样本都经过遗传分析。该提案的第三个目标是开发一个基于用户友好的基于网络的计算机平台，在该平台中，所有样本和相关的临床信息均已分类，以便通过寻找特定的组织类型，疾病，疾病或阶段进行搜索。与MRC Dementias平台英国信息学团队合作，我们将开发这样的平台。UCL神经退行性疾病人类神经组织资源将为该领域的组织提供逐步变化。